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MetabolomicsAccumulation of the coumarin scopolin under abiotic stress conditions is mediated by the Arabidopsis thaliana THO/TREX complex
Secondary metabolites are involved in the plant stress response. Among these are scopolin and its active form scopoletin, which are coumarin derivatives associated with reactive oxygen species scavenging and pathogen defence. Here we show that in Arabidopsis thaliana, scopolin accumulation can be in...
2018-02-05 | MTBLS389 | MetaboLights
TranscriptomicsGene expression profiles of Wnt-1 overexpressing melanoma
We aimed to analyze the effects of Wnt-1 overexpression on the mRNA expression profile of human melanoma in a mouse xenograft model and correlated the results with then presence or absence of lymphangiogenesis and metastasis. Affymetrix gene expression analysis revealed activation of canonical and n...
ORGANISM(S): Homo sapiens 
2012-06-04 | E-GEOD-26656 | biostudies-arrayexpress
TranscriptomicsTumor cell-specific inhibition of MYC function using small molecule inhibitors of the HUWE1 ubiquitin ligase
HUWE1 was depleted in Ls174T cells with an shRNA and the expression changes relative to a control shRNA were analyzed with microarray. Ls174T cells were treated with two separate HUWE1 inhibitor compounds (BI8622/BI8626) at concentrations of 20 uM and expression profiles relative to DMSO treated con...
ORGANISM(S): Homo_sapiens 
2014-10-22 | E-MTAB-1890 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human endothelial progenitor cells (EPC) vs. human umbilical vein endothelial cells (HUVEC) vs. CD14+ monocytes
Comparison of mRNA expression in human EPC vs. HUVEC vs. human monocytes. Cell-type specific gene expression under basal cell culture conditions (no stimulation). The hybridization was performed with three samples of EPC vs. three samples of HUVEC vs. 3 samples of CD14+ monocytes. â?¢ The origin of ...
ORGANISM(S): Homo sapiens 
2008-06-11 | E-GEOD-2040 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse primary capillary PlGF-/- endothelial cells treated with 100 ng/ml PlGF for 6 hours
PlGF expression profile in primary capillary PlGF-/- endothelial cells treated with 100 ng/ml PlGF during 6 hours.
ORGANISM(S): Mus musculus 
2003-05-28 | E-MEXP-6 | biostudies-arrayexpress
TranscriptomicsTumor cell-specific inhibition of MYC function using small molecule inhibitors of the HUWE1 ubiquitin ligase
Deregulated expression of MYC is a driver of colorectal carcinogenesis, necessitating novel strategies to inhibit MYC function. The ubiquitin ligase HUWE1 (HECTH9, ARFBP1, MULE) associates with both MYC and the MYC-associated protein MIZ1. We show here that HUWE1 is required for growth of colorecta...
ORGANISM(S): Homo sapiens 
2014-10-21 | E-GEOD-59223 | biostudies-arrayexpress
UnknownMyeloproliferative neoplasm (MPN) symptom assessment form total symptom score: prospective international assessment of an abbreviated symptom burden scoring system among patients with MPNs.
Not available
S-EPMC4872304 | biostudies-literature
GenomicsGenomic landscape of Epstein-Barr virus nuclear antigen 3A
We undertook ChIP-Seq of HA-tagged EBNA3A in Lymphoblastoid Cell Lines to understand the effects of this essential viral transcription factor on the cell DNA. We discovered that EBNA3A bound to DNA with BATF, IRF4 and RUNX3, making these Transcription Factors the ones that tether EBNA3A to DNA, allo...
ORGANISM(S): Homo sapiens 
2015-01-06 | E-GEOD-59181 | biostudies-arrayexpress
ModelsDallePezze2016 - Activation of AMPK and mTOR by amino acids
DallePezze2016 - Activation of AMPK and mTOR by amino acids (Model 3) This model is as described in the Supplementary Software 3 of the reference publication: SBML model similar to Model S2, but including a more complex p70-S6K module. This model is described in the article: A...
2024-09-02 | BIOMD0000000640 | BioModels
ModelsDallePezze2016 - Activation of AMPK and mTOR by amino acids (Model 2)
DallePezze2016 - Activation of AMPK and mTOR by amino acids (Model 2) This model is as described in the Supplementary Software 2 of the reference publication:  SBML model including four amino acids input in the network (simple p70-S6K module). This model is described in the article:...
2017-05-18 | MODEL1705030001 | BioModels
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