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TranscriptomicsMyc and Miz-1 control melanocyte senescence by regulating intracellular cystathionase levels
The development of malignant melanoma is a highly complex process which is still poorly understood despite extensive research. A majority of human melanomas are found to express a handful of oncogenic proteins, such as mutant RAS and BRAF. However, these oncogenes are also found in nevi, and it is n...
ORGANISM(S): Mus musculus 
2012-07-02 | E-GEOD-30473 | biostudies-arrayexpress
TranscriptomicsGeneration of highly tumorigenic cells from N-RAS61K-induced senescent cells
Activation of oncogene signaling in primary cells generally results in cellular senescence. This process is not only considered to be tumor-protective, but also irreversible. However, if senescence induction can be circumvented, e.g. by additional genetic or epigenetic changes, tumor progression oc...
ORGANISM(S): Mus musculus 
2014-01-20 | E-GEOD-27010 | biostudies-arrayexpress
TranscriptomicsRNA-seq of estrogen (E2) induced changes of mRNA expression in Sus scrofa male and female blastocysts derived from embryonic day 10
Environmental estrogens may affect epigenetic programming as early as the period of preimplantation development. Therefore, we analyzed the effects of continuous gestational estradiol-17β (E2) exposure on male and female embryos. A low dose, close to the no-observed effect level (NOEL - 10 µg E2/kg ...
ORGANISM(S): Sus scrofa 
2018-10-16 | E-MTAB-6263 | biostudies-arrayexpress
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