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TranscriptomicsRole of REG 1 in Entamoeba histolytica colitis
Differential expression was used to access gene differences after Entamoeba histolytica infection. Entamoeba histolytica is an important diarrheal pathogen worldwide, and induces apoptosis of the intestinal epithelium as part of its disease process. Regenerating (REG) 1 protein is anti-apoptotic. ...
ORGANISM(S): Homo sapiens 
2011-05-24 | E-GEOD-23750 | biostudies-arrayexpress
TranscriptomicsThe Effect of the Leptin Receptor Q223R Polymorphism on the Host Transcriptome Following Infection with E. histolytica.
Resistance to amebiasis is associated with a polymorphism in the leptin receptor. Previous studies demonstrated that humans with the ancestral Q223 leptin receptor allele were nearly four times less likely to be infected with Entamoeba histolytica than those carrying the mutant R223 allele. We hypot...
ORGANISM(S): Mus musculus 
2013-06-05 | E-GEOD-43372 | biostudies-arrayexpress
TranscriptomicsCharacterization of an Entamoeba histolytica High-Mobility-Group Box Protein Induced during Intestinal Infection
The unicellular eukaryote Entamoeba histolytica is a human parasite that causes amebic dysentery and liver abscess. A genome-wide analysis of gene expression modulated by intestinal colonization and invasion identified an up-regulated transcript that encoded a putative high-mobility-group box (HMGB)...
ORGANISM(S): Entamoeba histolytica 
2008-11-19 | E-GEOD-12204 | biostudies-arrayexpress
TranscriptomicsTargets of the E. histolytica transcription factor URE3-BP
The E. histolytica transcription factor URE3-BP is a calcium-responsive regulator of two E. histolytica virulence genes, hgl5 and fdx1. URE3-BP was previously identified by a yeast one-hybrid screen of E. histolytica proteins capable of binding to the sequence TATTCTATT (URE3) in the promoter region...
ORGANISM(S): Entamoeba histolytica 
2008-10-14 | E-GEOD-12188 | biostudies-arrayexpress
GenomicEpigenetic Analysis of Malnutrition

The PROVIDE study (Dhaka, Bangladesh) is a randomized clinical trial platform which evaluated the efficacy of delayed-dose oral rotavirus vaccine as well as the benefit of an injectable polio vaccine replacing one dose of oral polio vaccine. This rigorous infrastructure supported the additional e...

phs001073 | dbGaP
TranscriptomicsEGFR Mutation Promotes Glioblastoma Through Epigenome and Transcription Factor Network Remodeling
Epidermal Growth Factor Receptor (EGFR) gene amplification and mutations are the most common oncogenic events in Glioblastoma (GBM), but the mechanisms by which they promote aggressive tumor growth are not well understood. Here, through integrated epigenome and transcriptome analyses of cell lines, ...
ORGANISM(S): Homo sapiens 
2015-09-14 | E-GEOD-72468 | biostudies-arrayexpress
GenomicGenes Influencing Susceptibility to Infection and Malnutrition

NIH birth cohort study
Amebiasis is a common cause of diarrhea and is associated with malnutrition in grade-school aged children in an urban slum of Dhaka, Bangladesh. Field Studies of Human Immunity to Amebiasis in Bangladesh was designed to determine the contribution of amebiasis to...

phs001475 | dbGaP
TranscriptomicsComparison of Differences in Gene Expression in the Ventral Tegmental Area of 5 Pairs of Rat Lines Selectively Bred for High or Low Alcohol Consumption
The objective of this study was to determine common innate differences in gene expression in the ventral tegmental area (VTA) among the selectively bred (a) alcohol-preferring (P) vs. alcohol-non-preferring (NP) rats: (b) high-alcohol-drinking (HAD) vs. low-alcohol-drinking (LAD) rats (both replicat...
ORGANISM(S): Rattus norvegicus 
2012-07-31 | E-GEOD-31695 | biostudies-arrayexpress
UnknownGlobal burden of 292 causes of death in 204 countries and territories and 660 subnational locations, 1990-2023: a systematic analysis for the Global Burden of Disease Study 2023.
Not available
S-EPMC12535838 | biostudies-literature
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