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ProteomicsAffinity proteomics on PEX1 and PEX1-G843D in HCT116 Cells
The PEX1/PEX6 AAA-ATPase is required for the biogenesis and maintenance of peroxisomes. Mutations in HsPEX1 and HsPEX6 disrupt peroxisomal matrix protein import and are the leading cause of Peroxisome Biogenesis Disorders (PBDs). The most common disease-causing mutation in PEX1 is the HsPEX1G843D al...
ORGANISM(S): Homo sapiens (Human) 
2025-04-28 | PXD061295 | Pride
Human Flag-affinity Hct116 Pex1 
ProteomicsIdentification of interactors in structure of the peroxisomal AAA ATPase Pex1/Pex6
Identification of co-purified interaction partners of Pex1/Pex6 complex
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2023-10-24 | PXD043907 | Pride
Structure Pex1 Pex6 Cryoem 
TranscriptomicsA Drosophila model for the Zellweger spectrum of peroxisome biogenesis disorders
Human peroxisome biogenesis disorders are lethal genetic disease in which abnormal peroxisome assembly compromises overall peroxisome and cellular function. Peroxisomes are ubiquitous membrane-bound organelles involved in several important biochemical processes, notably lipid metabolism and the use ...
ORGANISM(S): Drosophila melanogaster 
2011-07-02 | E-GEOD-30362 | biostudies-arrayexpress
TranscriptomicsRetinas from the Pex1-G844D mouse model of Zellweger spectrum disorder
Gene expression analysis of retinas from a mouse model of the mild form of Zellweger spectrum disorder (ZSD). Mice homozygous for the hypomorphic Pex1-G844D allele, the murine ortholog of the human PEX1-G843D mutation found in a subset of patients with autosomal recessive ZSD, develop phenotypes fou...
ORGANISM(S): Mus musculus 
2013-12-15 | GSE52348 | GEO
TranscriptomicsRetinas from the Pex1-G844D mouse model of Zellweger spectrum disorder
Gene expression analysis of retinas from a mouse model of the mild form of Zellweger spectrum disorder (ZSD). Mice homozygous for the hypomorphic Pex1-G844D allele, the murine ortholog of the human PEX1-G843D mutation found in a subset of patients with autosomal recessive ZSD, develop phenotypes f...
ORGANISM(S): Mus musculus 
2013-12-15 | E-GEOD-52348 | biostudies-arrayexpress
UnknownDisorders of peroxisome biogenesis due to mutations in PEX1: phenotypes and PEX1 protein levels.
Not available
S-EPMC1226046 | biostudies-literature
UnknownCharacterization of two common 5' polymorphisms in PEX1 and correlation to survival in PEX1 peroxisome biogenesis disorder patients.
Not available
S-EPMC3167756 | biostudies-literature
UnknownPEX1 is essential for glycosome biogenesis and trypanosomatid parasite survival.
Not available
S-EPMC10952002 | biostudies-literature
UnknownThe peroxisomal AAA-ATPase Pex1/Pex6 unfolds substrates by processive threading.
Not available
S-EPMC5762779 | biostudies-literature
UnknownStructure of the peroxisomal Pex1/Pex6 ATPase complex bound to a substrate.
Not available
S-EPMC10518020 | biostudies-literature
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