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ProteomicsMulti-Omics Analysis Reveals RNA Polymerase II Degradation as a Novel Mechanism of PF-3758309's Anti-Tumor Activity
In this study, we conducted a comprehensive multi-omics analysis, including proteomics, transcriptomics, and ubiquitinomics, to investigate the mechanism of PF-3758309 in HCT116 cells. Our results revealed that PF-3758309 promotes the degradation of RNA polymerase II subunit proteins (POLR2A/B/E) vi...
ORGANISM(S): Homo Sapiens 
PXD064705 |
UnknownSmall-molecule p21-activated kinase inhibitor PF-3758309 is a potent inhibitor of oncogenic signaling and tumor growth.
Not available
S-EPMC2889050 | biostudies-literature
UnknownMulti-omics analysis reveals RNA polymerase II degradation as a novel mechanism of PF-3758309's anti-tumor activity.
Not available
S-EPMC12379277 | biostudies-literature
UnknownMechanism by Which PF-3758309, a Pan Isoform Inhibitor of p21-Activated Kinases, Blocks Reactivation of HIV-1 Latency.
Not available
S-EPMC9855626 | biostudies-literature
ProteomicsPhosphoproteomics identifies determinants of PAK inhibitor sensitivity in AML cells
Background The p21 activated kinases (PAK) are frequently dysregulated in cancer and have central roles in oncogenic signalling, prompting the development of PAK inhibitors (PAKi) as anticancer agents. However, such compounds have not reached clinical use because, at least partially, there is a lim...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD056514 | Pride
Acute myeloid leukaemia Phosphoproteomics Machine learning Kinase inhibitors Pak inhibitors Target therapy Pf-3758309 Proteomics Biomarkers Cancer 
GenomicsPrkaa1 in PDAC
Prkaa1 Overexpression, KO models, and PF-3758309 treatment
PRJEB63203 | ENA
UnknownPhosphoproteomics identifies determinants of PAK inhibitor sensitivity in leukaemia cells.
Not available
S-EPMC11907924 | biostudies-literature
UnknownA Novel AMPK Inhibitor Sensitizes Pancreatic Cancer Cells to Ferroptosis Induction.
Not available
S-EPMC11336956 | biostudies-literature
TranscriptomicsGenome-wide transcriptome analysis of PAK4 inhibition/knockdown in human bladder cancer cell line VMCUB1
Using multi-omic analyses, we identified PAK4 (P21 (RAC1) Activated Kinase 4) amplification and overexpression of Kinase PAK4 in a subset of bladder cancers. We confirmed the role of PAK4 in bladder cancer cell proliferation and invasion by in vitro experiments. Furthermore, our studies showed that ...
ORGANISM(S): Homo sapiens 
2020-04-20 | GSE130455 | GEO
Unknownp21-activated kinases as viable therapeutic targets for the treatment of high-risk Ewing sarcoma.
Not available
S-EPMC12830066 | biostudies-literature
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