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TranscriptomicsPeri-alloHCT IL-33 administration expands recipient T regulatory cells that protect mice against acute GvHD
Graft-versus-Host Disease (GvH) is the excessive inflammatory response by mature T cells contained in the graft during bone marrow transplantation. The allogeneic T cells recognize self-antigens as foreign and systemically attack multiple organs mostly with epithelial structures such as the skin, li...
ORGANISM(S): Mus musculus 
2016-06-27 | E-MTAB-4677 | biostudies-arrayexpress
TranscriptomicsGene profiling of HSCs in C57BL/6 TEL-SYK BM versus control
The aim of the study was to analyse gene expression differences in LT and ST HSCs in BM of TEL-SYK transplanted versus control C57BL/6mice
ORGANISM(S): Mus musculus 
2014-12-31 | E-MTAB-2240 | biostudies-arrayexpress
TranscriptomicsTracing the development of acute myeloid leukemia in CBL-syndrome
Comparison of copy number variations of acute myeloid leukemia mononuclear cells and the given cell types collected during complete remission of the acute myeloid leukemia
ORGANISM(S): Homo sapiens 
2014-02-12 | E-MEXP-3997 | biostudies-arrayexpress
UnknownMentalization-based treatment for adolescents with conduct disorder (MBT-CD): protocol of a feasibility and pilot study.
Not available
S-EPMC8252214 | biostudies-literature
TranscriptomicsDecitabine alters DNA methylation in AML patients
Sequential assessment of global mRNA expression in myeloblasts isolated from peripheral blood of eight AML patients treated with Decitabine within a phase II study (trial 00331). Total RNA was isolated after enrichment of peripheral blood myeloblasts directly before and directly after (median day 3)...
ORGANISM(S): Homo sapiens 
2012-12-12 | E-MEXP-3737 | biostudies-arrayexpress
TranscriptomicsRNAi profiling by array of human U202 cells with Cdh1shRNA knockdown to identify candidate interacting or target proteins of the anaphase-promoting complex_cyclosome
U2OS cells were transduced by a lentiviral vector carrying a Cdh1 shRNA and a puromycin resistance gene for selection. A vector carrying a GFP shRNA was used as control. The cells were stored in liquid N2 within 10 days after transduction in order to minimize the number of passages. Cells were thawe...
ORGANISM(S): Homo sapiens 
2010-09-10 | E-MEXP-2860 | biostudies-arrayexpress
TranscriptomicsMuscle fiber transdifferentiation in an experimental model of respiratory chain myopathy
Skeletal muscle fiber composition and muscle energetics are not static and change in muscle disease. This study was performed to determine if a mitochondrial myopathy is associated with adjustments in skelatal fiber type composition. These effects of drug induced mitochondrial dysfunction on skeleta...
ORGANISM(S): Rattus norvegicus 
2012-10-18 | E-MEXP-3642 | biostudies-arrayexpress
TranscriptomicsAnalysis of mouse T cell transcription profile after co-culture with BaF3 cells with or without the oncogenic point mutation JAK2 V617F
The activation of PD-1 (Programmed Death receptor-1) on T cells can cause T cell exhaustion and immune tolerance. Some tumors up-regulate the expression of the ligand of PD-1, namely PD-L1 (Programmed Death Receptor-Ligand 1), thus preventing anti-tumor immune response and promoting immune-escape. P...
ORGANISM(S): Mus musculus 
2018-12-01 | E-MTAB-5028 | biostudies-arrayexpress
TranscriptomicsExpression data from human peripheral blood lymphocytes stimulated with anti-CD3 and anti-CD28 antibodies.
Peripheral blood lymphocytes were separated in the Ficoll gradient and subjected for stimulation with anti-CD3 and anti-CD28 antiobodies upon time (6h, 12h and 18h). Next, total RNA was isolated and trenscriptional analysis of stimulated cells was performed. 11 total samples were analysed. Analysis ...
ORGANISM(S): Homo sapiens 
2013-02-25 | E-GEOD-29624 | biostudies-arrayexpress
TranscriptomicsDefinition and characterization of the systemic T cell dysregulation in untreated indolent B cell lymphoma and very early CLL
Epidemiological data show that the immune system may control or promote emergence and growth of a neoplastic lymphomatous clone. Conversely, systemic lymphomas, especially myeloma and CLL, are associated with clinical immunodeficiency. This prospective controlled study demonstrates substantially red...
ORGANISM(S): Homo sapiens 
2011-03-01 | E-GEOD-23293 | biostudies-arrayexpress
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