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ProteomicsPGC7-interacting proteins in HEK293T cells
Primordial germ cell 7 (PGC7), a maternal factor essential for early development, plays a critical role in the regulation of DNA methylation, transcriptional repression, chromatin condensation, and cell division and the maintenance of cell pluripotentiality. Despite the fundamental roles of PGC7 in ...
ORGANISM(S): Homo sapiens (Human) 
2017-07-28 | PXD006362 | Pride
Pgc7 hek293t lc-ms/ms 
GenomicsPGC7 and TET3 ChIP-seq results
PGC7 is a primordial germ cell (PGCs)-specific protein involved in epigenetic chromatin reprogramming in the zygote following fertilization. TET3 is a dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key rol...
ORGANISM(S): Homo sapiens 
2014-01-04 | E-GEOD-53809 | biostudies-arrayexpress
UnknownPGC7 suppresses TET3 for protecting DNA methylation.
Not available
S-EPMC3950671 | biostudies-literature
TranscriptomicsExpression data from cell lines forced expressed PGC7/Stella
Global DNA hypomethylation and DNA hypermethylation of promoter regions—including tumor suppressor genes—are frequently detected in human cancers. Although many studies have suggested a contribution to carcinogenesis, it is still unclear whether the aberrant DNA hypomethylation observed in tumor...
ORGANISM(S): Mus musculus 
2016-05-13 | E-GEOD-68837 | biostudies-arrayexpress
UnknownPGC7 regulates maternal mRNA translation via AKT1-YBX1 interactions in mouse oocytes.
Not available
S-EPMC11658377 | biostudies-literature
UnknownPGC7 maintains the pluripotency of F9 embryonic carcinoma cells by promoting Nanog translation.
Not available
S-EPMC12536462 | biostudies-literature
UnknownPGC7 Regulates Genome-Wide DNA Methylation by Regulating ERK-Mediated Subcellular Localization of DNMT1.
Not available
S-EPMC9958980 | biostudies-literature
UnknownPGC7 promotes tumor oncogenic dedifferentiation through remodeling DNA methylation pattern for key developmental transcription factors.
Not available
S-EPMC8185079 | biostudies-literature
GenomicsPGC7 and TET3 ChIP-seq results
PGC7 is a primordial germ cell (PGCs)-specific protein involved in epigenetic chromatin reprogramming in the zygote following fertilization. TET3 is a dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key rol...
ORGANISM(S): Homo sapiens 
2014-01-04 | GSE53809 | GEO
GenomicsHomo sapiens
PGC7 and TET3 ChIP-seq results
PRJNA233405 | ENA
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