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Microarray analysis of transcriptional changes in biopsies of solid tumors from patients treated in a Phase I study with the Cdk inhibitor PHA-793887. 7 patient biopsies pre- and post-treatment in dye swap. Tumors are of different origins, and are described in the accompanying manuscript.
ORGANISM(S): Homo sapiens 
The pha-4 locus encodes a forkhead box A (FoxA/HNF3) transcription factor homolog that specifies organ identity for Caenorhabditis elegans pharyngeal cells. We used microarrays to identify pharyngeal genes and analyzed those genes to determine which were direct PHA-4 targets. Our data suggest that P...
ORGANISM(S): Caenorhabditis elegans 
Bradyrhizobium sp. Pha-3 Genome sequencing
The effects of the CDK inhibitors PHA-848125 and PHA-690509 on the A2780 cell line were analysed by gene expression profiling. The A2780 cell line was treated with PHA-848125 (CDk-125) or PHA-690509 (CDk-509) for 6 hours at a dose equal to 5 times the IC50. Untreated A2780 cells were used as a contr...
ORGANISM(S): Homo sapiens 
Proteomic analysis was employed to elucidate the regulatory role of TtdR, a LysR-type transcriptional regulator located upstream of the glyoxylate carboligase gene (gcl) in Pseudomonas umsongensis GO16. While the wildtype strain can utilize ethylene glycol (EG) as a sole carbon and energy source, th...
ORGANISM(S): Pseudomonas umsongensis 
2026-09-07 | PXD075284 | Pride
Proteomic analysis was employed to elucidate the regulatory role of TtdR, a LysR-type transcriptional regulator located upstream of the glyoxylate carboligase gene (gcl) in Pseudomonas umsongensis GO16. While the wildtype strain can utilize ethylene glycol (EG) as a sole carbon and energy source, th...
ORGANISM(S): Pseudomonas umsongensis 
2026-09-07 | PXD075327 | Pride
Enhanced polyhydroxyalkanoate (PHA) production by a combined growth and storage response in waste activated sludge
PHA production mixed cultures Raw sequence reads
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