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ProteomicsMolecular effects of Vitamin C treatment in MSC80 cells, a suitable Schwann cell model
Schwann cells (SCs) are not only decisive to produce the axon-wrapping myelin sheath thus ensuring a proper nerve conduction but also exhibit with trophic function and can direct repair mechanisms of the peripheral nervous system. Consequently, suitable and well-characterized SC in vitro models are ...
ORGANISM(S): Mus musculus (Mouse) 
2018-08-13 | PXD006910 | Pride
Protein cataloguing Msc80 Tmx1 Schwann cells 
ProteomicsUnravelling MYO9A pathophysiology in CMS allows the identification of a therapeutic intervention concept
Congenital myasthenic syndromes (CMS) are a group of rare, inherited disorders characterised by compromised function of the neuromuscular junction (NMJ), manifesting with fatigable muscle weakness. Mutations in MYO9A were previously identified as causative for CMS but the precise pathomechanism rema...
ORGANISM(S): Mus musculus (Mouse) 
2018-10-24 | PXD007178 | Pride
Lc-msms Myo9a Nsc34 
ProteomicsMultifocal demyelinating motor neuropathy associated with a de novo PTEN mutation
Phosphatase and tensin homolog (PTEN) is a tumour suppressor gene associated with inherited tumour susceptibility conditions, macrocephaly, autism, ataxia, tremor and epilepsy. Functional implications of this protein have been investigated in Parkinson’s and Alzheimer’s diseases. We describe the fir...
ORGANISM(S): Homo sapiens (Human) 
2018-10-22 | PXD008014 | Pride
Pten Demyelinating motor neuropathy 
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