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ProteomicsQuantitative Proteomics Revealed the Changes of Pharmacodynamic Network of Bugu Shengsui Decoction Promoting Osteoblasts Proliferation
Insufficient osteogenesis is greatly essential to osteoporosis. Bugu Shengsui Decoction, a compound formula for osteoporosis, has significant clinical effects in the treatment of osteoporosis. Yet the detailed mechanisms are unclear. In this study, we first evaluated the pharmacological effects of B...
ORGANISM(S): Mus musculus (Mouse) 
2022-01-28 | PXD030275 | Pride
Osteoporosis Osteoblasts Bugu shengsui decoction Proliferation Quantitative proteomics Pi3k-akt Pharmacodynamic network 
ProteomicsProteomics and network pharmacology of Ganshu Nuodan capsules in the prevention of alcoholic liver disease
A mouse model of acute alcohol liver disease (ALD) induced by intragastric administration of 50% alcohol was used to evaluate the hepatoprotective effect of Ganshu Nuodan. The chemical constituents of Ganshu Nuodan were comprehensively identified by UPLC-QTOF/MS, and then its pharmacodynamic materia...
ORGANISM(S): Mus Musculus 
2023-09-08 | PXD045221 |
MetabolomicsXiaoyukang Capsules Promote Hematoma Absorption and Alleviate Neuronal Apoptosis via the Sema3A/NRP1-PI3K/AKT Signaling Axis in Rats with Intracerebral Hemorrhage

This study aimed to clarify the pharmacodynamic material basis and molecular mechanisms of Xiaoyukang Capsules (XYKC) in facilitating hematoma absorption and alleviating secondary nerve injury after intracerebral hemorrhage (ICH), and to identify its core therapeutic targets. Methods An ICH rat m...

2026-07-12 | MTBLS15015 | MetaboLights
TranscriptomicsFGFR signature
Drugs that target specific gene alterations have proven beneficial in the treatment of cancer. Because cancer cells have multiple resistance mechanisms, it is important to understand the downstream pathways of the target genes and monitor the pharmacodynamic markers associated with therapeutic effic...
ORGANISM(S): Homo sapiens 
2016-01-06 | E-GEOD-73024 | biostudies-arrayexpress
UnknownSystematic prediction of pharmacodynamic drug-drug interactions through protein-protein-interaction network.
Not available
S-EPMC3605053 | biostudies-literature
UnknownExploring the potential pharmacodynamic material basis and pharmacologic mechanism of the Fufang-Xialian-Capsule in chronic atrophic gastritis by network pharmacology approach based on the components absorbed into the blood.
Not available
S-EPMC6030346 | biostudies-literature
UnknownA General Network Pharmacodynamic Model-Based Design Pipeline for Customized Cancer Therapy Applied to the VEGFR Pathway.
Not available
S-EPMC3910016 | biostudies-literature
UnknownDobutamine Alters the Pharmacokinetic and Pharmacodynamic Behavior of Esmolol.
Not available
S-EPMC7819280 | biostudies-literature
GenomicsEvaluating MiRomics and Integrative Proteomics for Identification of Plasma miRNAs as Potential Pharmacodynamic Biomarkers of IFNβ-1a Biologics
Evaluating MiRomics and Integrative Proteomics for Identification of Plasma miRNAs as Potential Pharmacodynamic Biomarkers of IFNβ-1a Biologics
PRJNA1329123 | ENA
UnknownIntegrating network pharmacology, molecular docking and non-targeted serum metabolomics to illustrate pharmacodynamic ingredients and pharmacologic mechanism of Haizao Yuhu Decoction in treating hyperthyroidism.
Not available
S-EPMC11462413 | biostudies-literature
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