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MetabolomicsA human metabolome study for femoral neck osteoporosis in Kyoto

This dataset was generated to elucidate the metabolic features of femoral neck osteoporosis, a major risk factor for fractures and bedbound states in the elderly. Using whole-blood metabolomics, we analyzed the metabolic profiles of elderly individuals with and without femoral neck osteoporo...

2026-01-08 | MTBLS11650 | MetaboLights
MetabolomicsExploratory Multi-Omics Analysis of Gut Microbiota and Fecal Metabolites in Relation to Serum S-Equol Levels in Older Adults with Osteoporosis from a Tropical Community: A Pilot Study

This study aimed to investigate fecal metabolomic profiles associated with osteoporosis and serum S-equol levels in community-dwelling older adults from a tropical region of China. Fecal samples were collected from participants classified as osteoporosis or non-osteoporosis based on bone mineral ...

2026-02-10 | MTBLS13855 | MetaboLights
MetabolomicsArtemisiae Scopariae Herba (Yinchen) suppresses ferroptosis in osteoporosis mice via the Nrf2/SLC7A11/GPX4 pathway

With the aging of the population, the incidence of postmenopausal osteoporosis (PMOP) is increasing. Artemisiae Scopariae Herba (Yinchen, YC) extracts have been reported to promote osteogenic differentiation and bone formation, but the specific mechanism is ...

2025-09-26 | MTBLS13042 | MetaboLights
MetabolomicsParabacteroides distasonis Improving osteoporosis progression through glycerophospholipid metabolism_blood

Backround&Aim: Dysbiosis of gut microbiota is closely related to the pathogenesis of osteoporosis (OP). This study aimed to identify probiotic candidates and gut-derived metabolites capable of ameliorating osteoporosis via modulation of bone metabolism. 

Methods: Ovariect...

2025-08-01 | MTBLS12803 | MetaboLights
MetabolomicsIntegrated metagenomic and metabolomic analyses of the effects of total flavonoids of Rhizoma Drynariae on reducing ovariectomized-induced osteoporosis by regulating gut microbiota and related metabolites.

TFRD has been widely used in China to treat osteoporosis (OP). However, the specific molecular mechanism of TFRD against OP has not been fully clarified. Our previous studies have also proved that TFRD could attenuate OP and the clinical equivalent dose of 67.5 mg/kg/d is the effective dose for T...

2025-05-12 | MTBLS11866 | MetaboLights
MetabolomicsZingerone treats postmenopausal osteoporosis via increased ferroptosis sensitivity by p53-mediated regulation of Sat1 and Gpx4 expression

Zingerone, a component of dried ginger, has known anti-ulcer and bone growth-promoting effects, but its impact on postmenopausal osteoporosis (PO) is unclear. This study investigates the therapeutic potential and underlying mechanisms of zingerone in PO. A concentration-dependent effect identifie...

2025-08-07 | MTBLS12829 | MetaboLights
ProteomicsProteomic Analysis Based on TMT Regarding the Therapeutic Action of Rhizoma Drynariae on Rats in an Osteoporosis Model
Background: Primary osteoporosis has increasingly become one of the risk factors affecting human health, and the clinical effect and action mechanism of traditional Chinese medicine in the treatment of primary osteoporosis have been widely studied. Previous studies have confirmed that in traditional...
ORGANISM(S): Rattus norvegicus (Rat) 
2024-10-17 | PXD035745 | Pride
Osteoporosis Tmt . Rats Rhizoma drynariae Ovariectomized 
TranscriptomicsTranscriptome profiling identifies NETs-associated biomarkers in osteoporosis with diabetes
Background: Osteoporosis and diabetes represent major global public health challenges. Neutrophil extracellular traps (NETs) serve as key components of the innate immune system by capturing bacteria, fungi, and parasites, thereby trapping them in local environments with high concentrations of antimi...
ORGANISM(S): Homo sapiens 
2026-01-11 | E-MTAB-16559 | biostudies-arrayexpress
TranscriptomicsThe Role of PTHrP in Osteoblast Response to Microgravity: Implications for Osteoporosis Development.
Prolonged skeletal unloading through bedrest results in bone loss similar to that observed in elderly osteoporotic patients, but with an accelerated timeframe. This rapid effect on weight-bearing bones is also observed in astronauts who lose up to 2% of their bone mass per month spent in Space. Des...
ORGANISM(S): Mus musculus 
2016-08-09 | E-GEOD-78980 | biostudies-arrayexpress
UnknownThe additive effect of vitamin K supplementation and bisphosphonate on fracture risk in post-menopausal osteoporosis: a randomised placebo controlled trial.
Not available
S-EPMC10282078 | biostudies-literature
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