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MetabolomicsIntegrated metagenomic and metabolomic analyses of the effects of total flavonoids of Rhizoma Drynariae on reducing ovariectomized-induced osteoporosis by regulating gut microbiota and related metabolites.

TFRD has been widely used in China to treat osteoporosis (OP). However, the specific molecular mechanism of TFRD against OP has not been fully clarified. Our previous studies have also proved that TFRD could attenuate OP and the clinical equivalent dose of 67.5 mg/kg/d is the effective dose for T...

2025-05-12 | MTBLS11866 | MetaboLights
TranscriptomicsTranscription profiling of immature, ovariectomized C57BL/6 mice were treated with sesame oil (vehicle) or with 0.1 mg/kg 17-alpha-ethynylestradiol
Immature, ovariectomized C57BL/6 mice were treated with sesame oil (vehicle) or with 0.1 mg/kg 17-alpha-ethynylestradiol (EE) for the length of time indicated. Mice received one dose, except for the 3x24hr samples, which received 3 consecutive daily doses and were sacrificed 24hr after the final dos...
ORGANISM(S): Mus musculus 
2007-12-13 | E-GEOD-280 | biostudies-arrayexpress
ProteomicsEstradiol replacement modulates synaptic transmission-related proteins in the hippocampus of ovariectomized rats: an exploratory proteomic approach
Background: The loss of ovarian-derived hormones that characterizes postmenopause influences cognition, emotion and energy homeostasis, processes integrated by the hippocampus. The cellular and molecular mechanisms by which estradiol influences this brain system have not been fully understood. The p...
ORGANISM(S): Rattus norvegicus (Rat) 
2026-09-14 | PXD040816 | Pride
Synapse Postmenopause Glutamatergic synapse Mitochondrial dysfunction Vesicle-mediated transport Hormone therapy 
TranscriptomicsMolecular Analysis of the Vaginal Response to Estrogens in the Ovariectomized Rat and Postmenopausal Woman
Background. Vaginal atrophy (VA) is the thinning of the vaginal epithelial lining, typically the result of lowered estrogen levels during menopause. Some of the consequences of VA include increased susceptibility to bacterial infection, pain during sexual intercourse, and vaginal burning or itching....
ORGANISM(S): Rattus norvegicus 
2009-05-20 | E-GEOD-11622 | biostudies-arrayexpress
TranscriptomicsGlobal survey of miRNA microarray of uterus, ovariectomized female mice with or without estrogen (E2) treatment
To examine the effect of E2 treatment for the miRNA expression, at 15 week old, female wiled type mice were ovariectomized, and after one week, estradiol (E2) was delivered at a concentration of 0.050 mg/kg body weight/day. 24 hours after chemical treatment, uteruses from mice treated with or withou...
ORGANISM(S): Mus musculus 
2010-06-24 | E-GEOD-13858 | biostudies-arrayexpress
TranscriptomicsEffect of Diosgenin on the Circulating microRNA Profile of Ovariectomized Rats
To assess the changes in circulating microRNA (miRNA) expression profiles associated with the potential osteoprotective effect of diosgenin (DIO) in ovariectomized (OVX) rats.
ORGANISM(S): Rattus norvegicus 
2020-02-18 | E-MTAB-8502 | biostudies-arrayexpress
GenomicsEstradiol-dependent gene expression profile in the amygdala of ovariectomized SHRs
Estradiol-dependent gene expression profile in the amygdala of ovariectomized SHRs
PRJNA687479 | ENA
ProteomicsThe novel tRF-23 promotes osteogenic differentiation of hBMSCs and protects against bone loss in ovariectomized mice
The pathogenesis of osteoporosis is closely related to the impaired human bone marrow-derived stromal cells (hBMSCs) osteogenic differentiation. No studies to date, however, have established whether tRNA-derived fragments (tRFs) can influence osteogenic differentiation of hBMSCs or the onset of oste...
ORGANISM(S): Homo sapiens (Human) 
2026-01-19 | PXD067728 | Pride
Trf-23 Osteogenic differentiation Hbmscs Osteoporosis 
TranscriptomicsThe development and growth related transcriptome landscape of ovariectomized goat muscle
In this study, ovariectomized and normal ewe longissimus thoracis were used to thoroughly explore the global transcriptome to reveal how the castrated ewes influence muscle development by Illumina2000 sequencing technology. As a result, 1,612 differently expressed unigenes were revealed between ovar...
ORGANISM(S): Capra hircus 
2016-07-10 | GSE84110 | GEO
Transcriptomics24 hour time course: regulation of uterine genes by estradiol in ovariectomized mice
Using microarray technology, we compared the global expression pattern of uterine RNA from ovariectomized control mice to those of ovariectomized mice treated with estradiol for various intervals between 30 minutes and 24 hours. Keywords: estrogen, uterus, genomic, mouse
ORGANISM(S): Mus musculus 
2006-04-14 | GSE4664 | GEO
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