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UnknownIntegrating Pharmacoproteomics into Early-Phase Clinical Development: State-of-the-Art, Challenges, and Recommendations.
Not available
S-EPMC5343982 | biostudies-literature
UnknownPharmacoproteomics Profile in Response to Acamprosate Treatment of an Alcoholism Animal Model.
Not available
S-EPMC6287941 | biostudies-literature
UnknownPharmacoproteomics identifies combinatorial therapy targets for diffuse large B cell lymphoma.
Not available
S-EPMC4665772 | biostudies-literature
UnknownPharmacoproteomics Identifies Kinase Pathways that Drive the Epithelial-Mesenchymal Transition and Drug Resistance in Hepatocellular Carcinoma.
Not available
S-EPMC7484106 | biostudies-literature
UnknownPharmacoproteomics of Brain Barrier Transporters and Substrate Design for the Brain Targeted Drug Delivery.
Not available
S-EPMC9246989 | biostudies-literature
UnknownPharmacoproteomics reveal novel protective activity of bromodomain containing 4 inhibitors on vascular homeostasis in TLR3-mediated airway remodeling.
Not available
S-EPMC6699176 | biostudies-literature
ProteomicsPharmacoproteomics of non-human primate cerebrospinal fluid after BACE inhibition
The protease BACE1 is a major drug target for Alzheimer’s disease, but chronic BACE1 inhibition is associated with non-progressive worsening that may be caused by modulation of unknown physiological BACE1 substrates. To identify in vivo-relevant BACE1 substrates we applied pharmacoproteomics to non-...
ORGANISM(S): Macaca mulatta (Rhesus macaque) 
2023-02-23 | PXD035141 | Pride
Bace Beta secretase Cerebrospinal fluid Alzheimer's disease Csf 
ProteomicsBALF secretome and exosome proteomics
A systems-level pharmacoproteomics study of a standardized murine model of toll-like receptor (TLR)3-NFκB/RelA innated inflammation in the absence or presence of a highly selective Brd4 (ZL0454) or nonselective Bromodomain and Extraterminal domain inhibitor (JQ1).
ORGANISM(S): Mus musculus (Mouse) 
2019-07-16 | PXD012060 | Pride
Bromodomain containing protein 4  bronchoalveolar lavage fluid proteomics  airway fibrosis  epithelial mesenchymal transition  pericytes  mass spectrometry 
ProteomicsPharmacoproteomics identifies kinase pathways that drive the epithelial-mesenchymal transition and drug resistance in hepatocellular carcinoma
Hepatocellular carcinoma (HCC) is a complex and deadly disease lacking druggable genetic mutations. The limited efficacy of systemic treatments for advanced HCC implies that novel predictive biomarkers and drug targets are urgently needed. Most HCC drugs target protein kinases and their kinase-depen...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2018-12-15 | MSV000083236 | MassIVE
UnknownPharmacoproteomics pinpoints HSP70 interaction for correction of the most frequent Wilson disease-causing mutant of ATP7B.
Not available
S-EPMC7768786 | biostudies-literature
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