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MetabolomicsIntegrated transcriptome and metabolome dynamics with phenotypic traits reveal regulatory basis of male morphotype differentiation in giant freshwater prawn Macrobrachium rosenbergii

This integrated multi-omics resource delineates the molecular and phenotypic trajectories underlying male morphotype differentiation (Blue Claw [BC], Orange Claw [OC], Small Male [SM]) in macrobrachium rosenbergii during determinative developmental stages (100, 110, and 120 days pos...

2025-08-22 | MTBLS12876 | MetaboLights
ProteomicsCoordinate Enhancer Reprogramming by GATA3 and AP1 Promotes Phenotypic Plasticity to Achieve Breast Cancer Endocrine Resistance
Phenotypic plasticity has emerged as an important mechanism of therapy resistance in cancers, yet the underlying molecular mechanisms remain unclear. Using an established breast cancer cellular model for endocrine resistance, we show that hormone resistance is associated with enhanced phenotypic pla...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2019-05-24 | MSV000083857 | MassIVE
TranscriptomicsPhenotypic and transcriptional analysis of the osmotic regulator OmpR in Yersinia pestis
Background The osmotic regulator OmpR in Escherichia coli regulates differentially the expression of major porin proteins OmpF and OmpC. In Yersinia enterocolitica and Y. pseudotuberculosis, OmpR is required for both virulence and survival within macrophages. However, the phenotypic and regulatory r...
ORGANISM(S): Yersinia pestis 
2011-10-23 | E-GEOD-26601 | biostudies-arrayexpress
TranscriptomicsEvaluation of phenotypic plasticity in Rana temporaria tadpole development
Traditionally, the study of evolution has focused on heritable variation, because selection on non-heritable phenotypic variation was deemed non-important for its inability to cause evolutionary responses such as diversification of lineages. Recently however, it has been suggested that also environm...
ORGANISM(S): Rana temporaria 
2014-03-18 | E-GEOD-42274 | biostudies-arrayexpress
TranscriptomicsCardiac phase-targeted dynamic load on left ventricle differentially regulates phase-sensitive gene expressions and pathway activation
Each heart was assigned to one of the following three conditions: phasic systolic overload (SO), phasic diastolic overload (DO), and no loading throughout the cardiac cycle (control; CN). We created SO by isovolumic contraction (peak systolic LVP > 170 mmHg) at a constant diastolic volume with end-d...
ORGANISM(S): Rattus norvegicus 
2013-02-07 | E-GEOD-44108 | biostudies-arrayexpress
UnknownPhenotypic expressions of the optic disc in primary open-angle glaucoma.
Not available
S-EPMC10698030 | biostudies-literature
TranscriptomicsGene expression profiling differentiates autism case-controls and phenotypic variants of autism spectrum disorders
Autism spectrum disorders (ASD) are neurodevelopmental disorders characterized by delayed/abnormal language development, deficits in social interaction, repetitive behaviors and restricted interests. The heterogeneity in clinical presentation of ASD, likely due to different etiologies, complicates ...
ORGANISM(S): Homo sapiens 
2010-05-17 | E-GEOD-15402 | biostudies-arrayexpress
MetabolomicsImprovement of prediction ability by integrating multi-omic datasets in barley

BACKGROUND: Genomic prediction (GP) based on single nucleotide polymorphisms (SNP) has become a broadly used tool to increase the gain of selection in plant breeding. However, using predictors that are biologically closer to the phenotypes such as transcriptome and metabolome may...

2022-03-18 | MTBLS1561 | MetaboLights
UnknownFamilial aggregation analysis of gene expressions.
Not available
S-EPMC2367533 | biostudies-literature
UnknownComputerized analysis of facial expressions in serious mental illness.
Not available
S-EPMC8978090 | biostudies-literature
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