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PHF23 is a methyl reading protein with its PHD domain. We found PHF23 represses autophagy performed purification and identification of PHF23 interactome.
ORGANISM(S): Homo sapiens (Human) 
2025-12-15 | PXD065543 | Pride
We analyzed the genome wide localization of H3K4me3, H3K27me3 and the NUP98-PHF23 (with V5 tag) fusion protein which binds H3K4me3 via its PHD finger, using ChIP-seq. Results correlated with gene expression profiles. NUP98-PHF23 bound only 1.6% of H3K4me3 marks including Hoxa/b + Meis1. Assess H3K4m...
ORGANISM(S): Mus musculus 
Genome binding/occupancy profiling of PHF23 and changes in H3K27ac based on the presence of PHF23
NUP98-PHF23 is oncogenic and results in a Hoxa/b + Meis1 overexpression in NP23 leukemias and in premalignant (clinically healthy) hematopoietic tissues. Gene expression profiles from AML, pre-T LBL and B-ALL were compared to wild type bone marrow, thymus and spleen tissues respectively. Similarly, ...
ORGANISM(S): Mus musculus 
chromatin accessibility profiling by ATAC-seq based on the presence of PHF23
Transcriptome profiling based on the presence of PHF23 and amino acid starvation
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Mus musculus 
Phf23 regulates embryonic neurogenesis by increasing the level of H3K27ac of Tcf4 [CUT&Tag]
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