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TranscriptomicsDouble-stranded RNA induces molecular and inflammatory signatures that are directly relevant to COPD
Polyinosinic:polycytidylic acid (poly I:C) is a synthetic analogue of double-stranded (ds)RNA, a molecular pattern associated with viral infections, that is used to exacerbate inflammation in lung injury models. Despite its frequent use, there are no detailed studies of the responses elicited by a...
ORGANISM(S): Mus musculus 
2013-02-27 | E-GEOD-39304 | biostudies-arrayexpress
UnknownC-Reactive Protein-based Screening of People with Tuberculosis Symptoms: A Diagnostic Accuracy Study.
Not available
S-EPMC11936131 | biostudies-literature
UnknownC-reactive protein-based tuberculosis triage testing: a multi-country diagnostic accuracy study.
Not available
S-EPMC11071588 | biostudies-literature
UnknownHead-to-head comparison of diagnostic accuracy of TB screening tests: Chest-X-ray, Xpert TB host response, and C-reactive protein.
Not available
S-EPMC11213098 | biostudies-literature
TranscriptomicsBleomycin induces molecular changes directly relevant to idiopathic pulmonary fibrosis: A model for “active” disease
Genomic profiling of RNA from cultured human fibroblasts of donor samples in the 10-14th passage was carried out to determine expression changes in the fibroblasts of individual with different degrees of pulmonary fibrosis. Donors consisted of individuals with rapid progressing pulmonary fibrosis, s...
ORGANISM(S): Homo sapiens 
2013-04-10 | E-GEOD-44723 | biostudies-arrayexpress
TranscriptomicsBleomycin induces molecular changes directly relevant to idiopathic pulmonary fibrosis: A model for “active” disease.
Genomic profiling of bleomycin- and saline-treated mice across 7 timepoints (1, 2, 7, 14, 21, 28, 35 days post treatment) was carried out in C57BL6/J mice to determine the phases of response to bleomycin treatment which correspond to onset of active pulmonary fibrosis. Temporal genomic characterizat...
ORGANISM(S): Mus musculus 
2013-04-10 | E-GEOD-40151 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse ears exposed to sulfur mustard alone, sulfur mustard preceded by drug treatment, or vehicle compounds to identify gene expression changes that correlate with compound efficacy
Sulfur mustard (SM) is a potent alkylating agent. We are developing medical countermeasures to reduce the injury caused by SM exposure. Screening in the mouse ear vesicant model has identified three effective compounds: dimercaprol (British anti-lewisite), indomethacin, and octyl homovanillamide (OH...
ORGANISM(S): Mus musculus 
2007-12-01 | E-GEOD-2950 | biostudies-arrayexpress
TranscriptomicsTranscriptome profile of subcutaneous adipocytes isolated from obese vs. lean postmenopausal women
Adipocytes isolated from lean and obese postmenopausal women with no significant differences in metabolic syndrome parameters demonstrate changes in multiple inflammatory, metabolic and structural gene families. Purified adipocyte samples were isolated from subcutaneous adipose tissue surgical biops...
ORGANISM(S): Homo sapiens 
2013-02-02 | E-GEOD-44000 | biostudies-arrayexpress
GenomicsDe novo DNA methylation by DNA Methyltransferase 3a controls early effector CD8+ T cell fate decisions following activation
DNMT3a is a de novo DNA methyltransferase expressed robustly after T cell activation that regulates plasticity of CD4+ T cell cytokine expression. Here we show that DNMT3a is critical for directing early CD8+ T cell effector and memory fate decisions. While effector function of DNMT3a knockout T cel...
ORGANISM(S): Mus musculus 
2016-08-20 | E-GEOD-85823 | biostudies-arrayexpress
TranscriptomicsTranscriptome analysis of medulloblastoma tumors in mice
The proto-oncogene MYCN is mis-expressed in various types of human brain tumors. To clarify how developmental and regional differences influence transformation, we transduced wild-type or mutationally-stabilized murine N-mycT58A into neural stem cells (NSCs) from perinatal murine cerebellum, brain s...
ORGANISM(S): Mus musculus 
2012-03-20 | E-GEOD-36594 | biostudies-arrayexpress
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