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MetabolomicsCD73 inhibitor AB680 suppresses glioblastoma in mice by inhibiting purine metabolism and promoting P2RY12<sup>+</sup> microglia transformation.
CD73 (ecto-5'-nucleotidase) is a metabolic immune checkpoint that dephosphorylates AMP to produce adenosine. Adenosine plays a pivotal role in immunosuppressive tumor microenvironment (TME) through adenosine receptors expressed on various immune cells. AB680, a specific CD73 inhibitor, is currently ...
2025-08-04 | MTBLS11084 | MetaboLights
MetabolomicsThe phosphofructo-2-kinase/fructose-2,6-bisphosphatase-3 inhibitor 3PO is a modulator of neutrophil metabolism, ROS production and NET release
Neutrophils are key effector leukocytes of the innate immune system and play a pivotal role in defending the host against microbial infections. Recent studies have identified a crucial link between glycolysis and neutrophil cellular functions. We have investigated in human neutrophils, the intricate...
2025-08-14 | MTBLS6215 | MetaboLights
ProteomicsPeptide fingerprinting of eluates obtained from phosphatase inhibitor beads (PIBs)
Peptide fingerprinting to verify the efficacy of phosphatase inhibitor beads (PIBs) for capturing Spodoptera frugiperda (Sf9) phosphatases of the PP2A family.
ORGANISM(S): Homo sapiens (Human) Spodoptera frugiperda 
2025-03-13 | PXD045891 | Pride
Human phlpp2 Phosphatase inhibitor 
TranscriptomicsIntegrative transcriptome profiling of cognitive aging and its preservation through Ser/Thr protein phosphatase regulation
Environmental enrichment has been reported to delay or restore age-related cognitive deficits, however, a mechanism to account for the cause and progression of normal cognitive decline and its preservation by environmental enrichment is lacking. Using genome-wide SAGE-Seq, we provide a global assess...
ORGANISM(S): Mus musculus 
2015-06-24 | E-GEOD-43718 | biostudies-arrayexpress
TranscriptomicsMapping and characterization of promoter-binding sites of protein phosphatase 1
Protein phosphatase 1 (PP1) is a Ser/Thr phosphatase that has been implicated in many key cellular functions including transcriptional regulation. Due to its involvement these many processes, it becomes difficult to directly link PP1 to transcriptional regulation on the chromatin level as no direct ...
ORGANISM(S): Homo sapiens 
2015-06-17 | E-GEOD-54170 | biostudies-arrayexpress
TranscriptomicsDisrupted interaction of transmembrane prostatic acid phosphatase and snapin will lead to prostate cancer
Disrupted interaction of transmembrane prostatic acid phosphatase and snapin will lead to prostate cancer
ORGANISM(S): Mus musculus 
2013-09-12 | E-MTAB-1191 | biostudies-arrayexpress
ProteomicsComparative proteomics of reduced protein phosphatase inhibitor-2 expression in the loss of function mutant Arabidopsis
Protein phosphatase inhibitor-2 (PPI-2) is a conserved eukaryotic effector protein that inhibits type one protein phosphatases (TOPP). A transfer-DNA knockdown of AtPPI-2 resulted in stunted growth in both vegetative and reproductive phases of Arabidopsis development. At the cellular level, AtPPI-2 ...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2017-12-14 | PXD006568 | Pride
Arabidopsis Comparative proteomics Type-1 phosphatase Protein-protein interaction Ppi-2 Ribosome biogenesis Phosphatase inhibitor 
TranscriptomicsTherapeutic effect of γ-secretase inhibition in KrasG12V-driven non-small cell lung carcinoma through derepression of DUSP1 phosphatase and inhibition of ERK
We have investigated the role of the Notch pathway in the generation and maintenance of KrasG12V-driven non-small cell lung carcinomas (NSCLCs). We demonstrate by genetic means that γ-secretase and Rbpj activities are both essential in the formation of NSCLCs. Interestingly, pharmacologic treatment ...
ORGANISM(S): Homo sapiens 
2012-12-01 | E-GEOD-38054 | biostudies-arrayexpress
TranscriptomicsThe tinkerbell (tink) mutation identifies the dual-specificity MAPK phosphatase INDOLE-3-BUTYRIC ACID-RESPONSE5 (IBR5) as a novel regulator of organ size in Arabidopsis.
Mitogen-activated dual-specificity MAPK phosphatases are important negative regulators in the MAPK signalling pathways responsible for many essential processes in plants. In a screen for mutants with reduced organ size we have identified a mutation in the active site of the dual-specificity MAPK ph...
ORGANISM(S): Arabidopsis thaliana 
2015-07-30 | E-GEOD-66419 | biostudies-arrayexpress
TranscriptomicsProtein phosphatase 2A protects centromeric sister chromatid cohesion during meiosis I
Segregation of homologous maternal and paternal centromeres to opposite poles during meiosis I depends on post-replicative crossing over between homologous non-sister chromatids, which creates chiasmata and therefore bivalent chromosomes. Destruction of sister chromatid cohesion along chromosome arm...
ORGANISM(S): Saccharomyces cerevisiae 
2010-06-11 | E-GEOD-4791 | biostudies-arrayexpress
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