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TranscriptomicsGene Expression Profiling of human leukemic B-cells. Two-color Microarray-Based Gene Expression Analysis.
Fresh MEC1 cells (chronic lymphocytic leukemia) (ACC-497, DSMZ) previously untreated and treated in cultures in vitro with glycodendrimers (nanoparticle with maltotriose on the surface). MEC1 cells were centrifuged after incubation with drugs or dendrimers. Agilent’s Low Input Quick Amp Labeling Kit...
ORGANISM(S): Homo sapiens 
2015-04-22 | E-GEOD-68094 | biostudies-arrayexpress
UnknownA methionine aminopeptidase-2 inhibitor, PPI-2458, for the treatment of rheumatoid arthritis.
Not available
S-EPMC490009 | biostudies-literature
UnknownNAPAbench 2: A network synthesis algorithm for generating realistic protein-protein interaction (PPI) network families.
Not available
S-EPMC6984706 | biostudies-literature
UnknownA pyridine dicarboxylate based hydrazone Schiff base for reversible colorimetric recognition of Ni2+ and PPi.
Not available
S-EPMC10201394 | biostudies-literature
TranscriptomicsA protein network of common susceptibility genes provides a link in the genetic architecture of chronic inflammation and cardiovascular disease
Genome-wide association studies (GWAS) have identified hundreds of susceptibility loci for chronic and inflammatory disease phenotypes in humans. There is increasing evidence that chronic inflammation is a crucial driver in the pathogenesis of cardiovascular diseases (CVD), which may be genetically ...
ORGANISM(S): Homo sapiens 
2015-09-01 | E-GEOD-54989 | biostudies-arrayexpress
TranscriptomicsIntegrating Large-Scale Functional Genomic Data to Dissect the Complexity of Yeast Regulatory Networks
A major goal of biology is the construction of networks that predict complex system behavior. We combine multiple types of molecular data, including genotypic, expression, transcription factor binding site (TFBS), and protein-protein interaction (PPI) data previously generated from a number of yeas...
ORGANISM(S): Saccharomyces cerevisiae 
2008-06-15 | E-GEOD-11111 | biostudies-arrayexpress
ProteomicsComparative proteomics of reduced protein phosphatase inhibitor-2 expression in the loss of function mutant Arabidopsis
Protein phosphatase inhibitor-2 (PPI-2) is a conserved eukaryotic effector protein that inhibits type one protein phosphatases (TOPP). A transfer-DNA knockdown of AtPPI-2 resulted in stunted growth in both vegetative and reproductive phases of Arabidopsis development. At the cellular level, AtPPI-2 ...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2017-12-14 | PXD006568 | Pride
Arabidopsis Comparative proteomics Type-1 phosphatase Protein-protein interaction Ppi-2 Ribosome biogenesis Phosphatase inhibitor 
UnknownDensePPI-2: a bio-inspired update for sequence-based PPI prediction leveraging mutation rates
Not available
S-EPMC12341865 | biostudies-literature
TranscriptomicsResponse of peripheral blood mononuclear cells from 15 healthy donor and 15 patients with type 1 diabetes to type 1 diabetogenic protein (GAD65, IGRP, PPI, ZnT8) and influenza virus M derived peptide stimulation.
CD4 T cell responses are characterized based on a limited number of molecular markers selected from exisiting knowledge. The goal of the experiment was to assess antigenic-peptide specific T-cell responses in vitro without bias using microarrays. PBMCs were isolated from 15 healthy donors and 15 pat...
ORGANISM(S): Homo sapiens 
2016-08-15 | E-GEOD-72376 | biostudies-arrayexpress
TranscriptomicsA protein network of common susceptibility genes provides a link in the genetic architecture of chronic inflammation and cardiovascular disease
Genome-wide association studies (GWAS) have identified hundreds of susceptibility loci for chronic and inflammatory disease phenotypes in humans. There is increasing evidence that chronic inflammation is a crucial driver in the pathogenesis of cardiovascular diseases (CVD), which may be genetically ...
ORGANISM(S): Homo sapiens 
2015-09-01 | GSE54989 | GEO
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