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ProteomicsA chemoproteomics approach to profile phospholipase D-derived phosphatidyl alcohol interactions
Alcohol consumption leads to formation of phosphatidylethanol (PEth) via the transphosphatidylation activity of phospholipase D (PLD) enzymes. Though this non-natural phospholipid routinely serves as a biomarker of chronic alcoholism, its pathophysiological roles remain unknown. We use a minimalist ...
ORGANISM(S): Homo sapiens (Human) 
2024-01-04 | PXD029749 | Pride
Cuaac Basigin Phosphatidyl ethanol Phosphatidic acid Diazirene Photoaffinity label Click chemistry Phospholipase d Phosphatidyl alcohol 
UnknownEnzymatic synthesis of phosphatidyl-EPA/DHA using Candida antarctica lipase B immobilized on mesoporous MIL-88 A.
Not available
S-EPMC12583253 | biostudies-literature
MetabolomicsMechanisms of hepatic steatosis in chickens: integrated analysis of the host genome, molecular phenomes and gut microbiome

Hepatic steatosis is the initial manifestation of abnormal liver functions and often leads to liver diseases such as non-alcoholic fatty liver disease in humans and fatty liver syndrome in animals. In this study, we conducted a comprehensive analysis of a large chicken population consisting of 70...

2023-07-24 | MTBLS7808 | MetaboLights
TranscriptomicsAKT Isoform Specificity Downstream of PIK3CA Mutation Impacts Estradiol and PI3K Inhibitor Response in Breast Cancer Cells
Background: PIK3CA mutations are observed in >30% of breast cancers, which are more common in estrogen receptor (ERα)-positive breast cancer compared with ERα-negative breast cancer. AKT1, 2, and 3 isoforms, major isoforms downstream of PI3K, modulate ERα activity. It is unknown whether PIK3CA mu...
ORGANISM(S): Homo sapiens 
2016-08-10 | E-GEOD-60759 | biostudies-arrayexpress
TranscriptomicsGenome-wide expression profiling of SGTA knockdown in C4-2B prostate cancer cells
Identifying the effect of the co-chaperone SGTA on global androgen receptor transcriptional activity in C4-2B prostate cancer cells with view to further elucidating the broader biological role of SGTA on other signaling pathways within prostate cancer cells Knockdown of SGTA for 72 hours in C4-2B ce...
ORGANISM(S): Homo sapiens 
2013-01-30 | E-GEOD-43521 | biostudies-arrayexpress
UnknownBiomarkers of moderate alcohol intake and alcoholic beverages: a systematic literature review.
Not available
S-EPMC10114415 | biostudies-literature
TranscriptomicsTranscription profiling of human CD4+ leukemia Jurkat T-cells in which the PI3K pathway is constitutively turned-on and FOXO1 transcriptional activity strongly repressed
One major effect of PI3-kinase activation downstream of the serine/threonine kinase Akt is the phosphorylation of the transcription factor FOXO1 and its neutralization. FOXO1 has several ubiquitous targets genes in many cell types that control cell quiescence, oxydative stress or apoptosis. However,...
ORGANISM(S): Homo sapiens 
2008-12-01 | E-TABM-391 | biostudies-arrayexpress
UnknownGemini Cationic Lipid-Type Nanovectors Suitable for the Transfection of Therapeutic Plasmid DNA Encoding for Pro-Inflammatory Cytokine Interleukin-12.
Not available
S-EPMC8156092 | biostudies-literature
MetabolomicsCholesterol maintains the degradative capacity of lysosomes during clearance and recycling of dysfunctional mitochondria
Efficient clearance and recycling of dysfunctional mitochondria through the robust catabolic activity of lysosomes is essential for cellular health. However, how membrane lipids contribute to maintaining the degradative capacity of lysosomes remains poorly understood. Here, we show that cholesterol ...
2026-07-30 | MTBLS15181 | MetaboLights
UnknownSpironolactone hyaluronic acid enriched cerosomes (HAECs) for topical management of hirsutism: in silico studies, statistical optimization, ex vivo, and in vivo studies.
Not available
S-EPMC8567875 | biostudies-literature
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