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MetabolomicsNPC1 regulates the distribution of phosphatidylinositol 4 kinases at Golgi and Lysosome membranes
Cholesterol and phosphoinositides (PI) are two critically important lipids that are found in cellular membranes and dysregulated in many disorders. Therefore, uncovering molecular pathways connecting these essential lipids may offer new therapeutic insights. We report that loss of function of lysoso...
2021-09-15 | MTBLS2612 | MetaboLights
MetabolomicsMMD collaborates with ACSL4 and MBOAT7 to promote polyunsaturated phosphatidylinositol remodeling and susceptibility to ferroptosis

Ferroptosis is a form of regulated cell death with roles in degenerative diseases and cancer. Excessive iron-catalyzed peroxidation of membrane phospholipids, especially those containing the polyunsaturated fatty acid arachidonic acid (AA), is central in driving ferroptosis. Here, we reveal that ...

2023-09-06 | MTBLS8280 | MetaboLights
MetabolomicsDBA2J Phosphatidylinositol Analysis
Not available
ORGANISM(S): Mus musculus 
ST000581 | MetabolomicsWorkbench
MetabolomicsAngiopoietin-like 4 governs diurnal lipoprotein lipase activity in brown adipose tissue.

OBJECTIVE: Brown adipose tissue (BAT) burns fatty acids (FAs) to produce heat, and shows diurnal oscillation in glucose and triglyceride (TG)-derived FA-uptake, peaking around wakening. Here we aimed to gain insight in the diurnal regulation of metabolic BAT activity.

2023-11-15 | MTBLS4082 | MetaboLights
ProteomicsRegulation of the microsomal proteome by salicylic acid and deficiency of phosphatidylinositol‐4‐kinases β1 and β2 in Arabidopsis thaliana
Phosphatidylinositol-4-kinases β1 and β2 (PI4Kβ1/PI4Kβ2), which are responsible for phosphorylation of phosphoinositol to phosphatidylinositol-4-phosphate, have an important role in vesicular trafficking in plants. Moreover, PI4Kβ1/PI4β2 negatively regulate biosynthesis of phytohormone salicylic aci...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2021-02-24 | PXD019737 | Pride
Arabidopsis thaliana Microsomal fraction Phosphatidylinositol-4-kinases β1 and β2 Salicylic acid Label-free quantification Lc-ms/ms 
GenomicsInactivation of phosphatidylinositol 4-kinase IIIalpha (PI4KA) by GSK-A1 inhibitor in HEK293 cells
Inactivation of phosphatidylinositol 4-kinase IIIalpha (PI4KA) by GSK-A1 inhibitor in HEK293 cells
PRJNA1297159 | ENA
TranscriptomicsInactivation of phosphatidylinositol 4-kinase IIIalpha (PI4KA) by GSK-A1 inhibitor in HEK293 cells
Phosphatidylinositol 4-kinases (PI4Ks) are lipid kinase enzymes that play important roles in cellular signaling, membrane trafficking, viral replication and lipid metabolism. They catalyze the phosphorylation of phosphatidylinositol (PI) to produce phosphatidylinositol 4-phosphate (PI4P) at various ...
ORGANISM(S): Homo sapiens 
2025-12-04 | GSE303723 | GEO
ProteomicsMolecular mechanism of β-arrestin-2 pre-activation by phosphatidylinositol 4,5-bisphosphate
Arrestins are a protein family that regulate G protein-coupled receptor (GPCR) signaling, with four distinct members in mammals (arrestin 1–4). Phosphorylated residues of G protein-coupled receptors bind to the N-domain of arrestin, resulting in C-terminus release. This induces further allosteric co...
ORGANISM(S): Rattus norvegicus (Rat) 
2024-07-15 | PXD049391 | Pride
Arrestin Hydrogen/deuterium exchange mass spectrometry (hdx-ms) 5-bisphosphate Phosphatidylinositol 4 
GenomicsPhosphatidylserine and RhoB connect phosphatidylinositol 4-phosphate and phosphatidic acid metabolism at the plasma membrane
Phosphatidylserine and RhoB connect phosphatidylinositol 4-phosphate and phosphatidic acid metabolism at the plasma membrane
PRJNA1330818 | ENA
TranscriptomicsTranscription profiling of human HCMV-Infected monocytes
Human cytomegalovirus induces a pro-inflammatory monocyte following infection and we have evidence that NF-κB and phosphatidylinositol 3-kinase [PI(3)K] are key mediators in this early activation. To begin to address how these signalling pathways are responsible for the rapid activation of infecte...
ORGANISM(S): Homo sapiens 
2008-06-16 | E-GEOD-9601 | biostudies-arrayexpress
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