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MetabolomicsSCP4-STK35/PDIK1L complex is a dual phospho-catalytic signaling dependency in acute myeloid leukemia
Acute myeloid leukemia (AML) cells rely on phospho-signaling pathways to gain unlimited proliferation potential. Here, we used domain-focused CRISPR screening to identify the nuclear phosphatase SCP4 as a dependency in AML, yet this enzyme is dispensable in normal hematopoietic progenitor cells. Usi...
2025-05-29 | MTBLS3707 | MetaboLights
ProteomicsEvaluation of phospho-tyrosine antibodies for label-free phosphoproteomics
In the past decade multiple tyrosine kinase inhibitors (TKIs) have been implemented in standard treatment regimens for patients with cancer. Unfortunately the majority of patients develops resistance to these drugs. Reliable tools for analysis of pharmacodynamic effects and drug resistance mechanism...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-10-21 | MSV000080270 | MassIVE
ProteomicsTime resolved quantitative phospho-tyrosine analysis reveals Bruton’s Tyrosine kinase mediated signaling downstream of the mutated granulocyte-colony stimulating factor receptors
Granulocyte-colony stimulating factor receptor (G-CSFR) controls myeloid progenitor proliferation and differentiation to neutrophils. Mutations in CSF3R (encoding G-CSFR) have been reported in patients with chronic neutrophilic leukemia (CNL) and acute myeloid leukemia (AML); however, despite years ...
ORGANISM(S): Mus musculus (Mouse) 
2018-07-11 | PXD009662 | Pride
Aml Ruxolitinib Silac Ibrutinib Phosphoproteomics Cnl Lc-ms/ms 
MetabolomicsIdentifying metabolite changes in human islets treated with Phospho-BAD mimicry and Inflammatory cytokines
Not available
ORGANISM(S): Homo sapiens 
ST001953 | MetabolomicsWorkbench
ProteomicsThe Arabidopsis tyrosine phosphatase RLPH2 targets D-group MAP kinases
Knowing that biochemically RLPH2 is a tyrosine phosphatase, we selectively In an attempt to discover RLPH2 substrates we decided to use the power of phospho-proteomics. Immunoprecipitated tyrosine phosphorylated peptides from enriched phospho-peptide pools derived from these plant extracts. Mass spe...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2026-01-26 | PXD038689 | Pride
Phosphoproteomics Arabidopsis Protein phosphatase Mapk 
ProteomicsProtein tyrosine kinases analysis by multiplexed parallel reaction monitoring assays
In this study, we have developed a parallel reaction monitoring (PRM)-based assay for quantitative profiling of 83 PTKs. The assay detects 308 proteotypic peptides from 54 receptor tyrosine kinases and 29 nonreceptor tyrosine kinases in a single run. We used this assay to determine PTKs in lung canc...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2015-08-12 | MSV000079224 | MassIVE
Proteomics012819 Hawse phospho Tyrosine dataset
In order to determine early signaling in T-cell activations we have profiled proteins that contain phosphorylated Tyrosine residues.
ORGANISM(S): Mus musculus (Mouse) 
2020-05-04 | PXD017871 | Pride
T-cell Phospho tyrosine 
TranscriptomicsThe ShcA PTB Domain Functions as a Biological Sensor of Phospho-tyrosine Signaling During Breast Cancer Progression
The ShcA adaptor possesses two phosphotyrosine binding motifs, which include an SH2 and a PTB domain. In the majority of cases, ShcA utilizes its PTB domain to engage activated receptor tyrosine kinases (RTKs). To establish the mportance of this domain during mammary tumorigenesis, we employed a Sh...
ORGANISM(S): Mus musculus 
2013-08-07 | E-GEOD-41718 | biostudies-arrayexpress
ProteomicsBead-based kinase phosphorylation profiling identifies SRC as a therapeutic target in glioblastoma
Here we describe a bead-based method capable of profiling tyrosine kinase phosphorylations in a multiplexed, high-throughput and low-cost manner. This approach allows for the discovery of tyrosine kinase-activating events, even when the DNA sequence is wild-type. In an effort to pilot the establishm...
ORGANISM(S): Homo sapiens 
2010-06-24 | E-GEOD-13808 | biostudies-arrayexpress
ProteomicsLung_pY profiling - Profiling phospho-tyrosine levels in mosue tumors which were xenografted from pateint lung tumor.
Profiling phospho-tyrosine levels in mosue tumors which were xenografted from pateint lung tumor.
ORGANISM(S): Homo sapiens (Human) 
2018-09-07 | PXD000809 | Pride
Py profiling Lung Ptm Xenograft Lc-ms/ms 
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