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MetabolomicsEpithelial-Cell-Derived Phospholipase A2 Group 1B Is an Endogenous Anthelmintic
Immunity to intestinal helminth infections has been well studied, but the mechanism of helminth killing prior to expulsion remains unclear. Here we identify epithelial-cell-derived phospholipase A2 group 1B (PLA2g1B) as a host-derived endogenous anthelmintic. PLA2g1B is elevated in resistant mice an...
2018-08-13 | MTBLS523 | MetaboLights
MetabolomicsTargeting phospholipase PLAG-15 promotes healthy aging in C. elegans via lysosomal-related genes
Complex lipid metabolism plays a crucial role in regulating aging. We recently discovered that the phospholipid bis(monoacylglycero)phosphate (BMP) increases in aged human muscles and many mouse tissues. The phospholipase PLA2G15 is reportedly involved in BMP synthesis, however, its specific role in...
2025-06-19 | MTBLS12324 | MetaboLights
MetabolomicsPhospholipase D3 impact on the endolysosomal lipidome
Not available
ORGANISM(S): Homo sapiens 
ST002334 | MetabolomicsWorkbench
TranscriptomicsTranscription profiling of human HepG2 cells overexpressing GPI-phospholipase D vs control sampled at 2 time points
A time course of the effect of overexpressing GPI-PLD on global gene expression in HepG2 cells was compared to control virus. Experiment Overall Design: This experiment compares the global gene expression in HepG2 cells that were either transduced with an adenovirus expressing GPI-phospholipase D or...
ORGANISM(S): Homo sapiens 
2007-10-26 | E-GEOD-4731 | biostudies-arrayexpress
MetabolomicsThe interaction of ceramide-1-phosphate with group IVA cytosolic phospholipase A2 modulates neutrophil polarization during inflammatory responses
Not available
ORGANISM(S): Mus musculus 
ST002445 | MetabolomicsWorkbench
TranscriptomicsExpression data from rat (Sprague Dawley) brain subjected to MCAo.
Middle cerebral artery occlusion (MCAo) in rat represent the ischemic stroke in human. Rodents subjected to MCAo and treated with venom phospholipase A2 showed reduction in infarct volume after 24hours of stroke. We studied the global gene expression of the reduction in infarct volume using Affymetr...
ORGANISM(S): Rattus norvegicus 
2009-09-04 | E-GEOD-17929 | biostudies-arrayexpress
TranscriptomicsExpression analysis with Phospholipase C over expression
The regulation of phospholipid biosynthesis in Saccharomyces cerevisiae through cis-acting upstream activating sequence inositol (UASino) and trans-acting elements, such as the INO2-INO4 complex and OPI1 by inositol supplementation in growth is thoroughly studied. In this study, we provide evidence ...
ORGANISM(S): Saccharomyces cerevisiae 
2012-09-01 | E-GEOD-35745 | biostudies-arrayexpress
TranscriptomicsExpression analysis with Phospholipase C over expression
The regulation of phospholipid biosynthesis in Saccharomyces cerevisiae through cis-acting upstream activating sequence inositol (UASino) and trans-acting elements, such as the INO2-INO4 complex and OPI1 by inositol supplementation in growth is thoroughly studied. In this study, we provide evidence ...
ORGANISM(S): Saccharomyces cerevisiae 
2012-04-23 | E-GEOD-35677 | biostudies-arrayexpress
ProteomicsA chemoproteomics approach to profile phospholipase D-derived phosphatidyl alcohol interactions
Alcohol consumption leads to formation of phosphatidylethanol (PEth) via the transphosphatidylation activity of phospholipase D (PLD) enzymes. Though this non-natural phospholipid routinely serves as a biomarker of chronic alcoholism, its pathophysiological roles remain unknown. We use a minimalist ...
ORGANISM(S): Homo sapiens (Human) 
2024-01-04 | PXD029749 | Pride
Cuaac Basigin Phosphatidyl ethanol Phosphatidic acid Diazirene Photoaffinity label Click chemistry Phospholipase d Phosphatidyl alcohol 
ProteomicsThe Legionella protein VpdC is a ubiquitin-activated phospholipase effector
The goal of this project was to identify the host factor(s) required for allosteric activation of the phospholipase VpdC from the intracellular pathogen Legionella pneumophila. For that reason, we performed co-precipitation analyses from lysate of transiently transfected HEK293T cells producing eith...
ORGANISM(S): Legionella pneumophila Legionella pneumophila 
2023-06-12 | PXD037059 | Pride
Host-pathogen interaction  intracellular pathogen  legionnaires' disease  translocated effector  host cell 
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