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ProteomicsNIK expression stimulated G6PD phosphorylation
Our findings establish NIK as a pivotal regulator of T cell metabolism in anti-tumor immunity and highlight a posttranslational mechanism of metabolic regulation involving the G6PD-NADPH redox system. CoIP assays revealed a strong physical interaction between NIK and G6PD in both T cells and transie...
ORGANISM(S): Homo sapiens (Human) 
2020-10-05 | PXD020943 | Pride
Nik G6pd Phosphoralytion 
ProteomicsShort-term mild temperature-stress-induced alterations in C. elegans phosphoproteome
Exposure to mild early-life stresses can slow down the aging process, in which protein phosphorylation might be an essential regulator. Currently, the understanding of phosphorylation-based regulatory networks under mild early-life stress remains elusive. Herein, we systematically analyzed the phosp...
ORGANISM(S): Caenorhabditis elegans 
2020-09-17 | PXD021081 | Pride
Phosphoproteomics  c. elegans  mild temperature  lifespan  mild stresses 
ProteomicsQuantitative temporal phosphoproteomics of aging C.elegans under different environmental temperatures
Temperature is one of the primary environmental factors that affect aging, in which protein phosphorylation is an important regulator. Currently, the understanding of phosphorylation events in regulatory networks during aging has remained rather limited. Therefore, the phosphoproteomes of C.elegans ...
ORGANISM(S): Caenorhabditis elegans 
2018-08-08 | PXD009661 | Pride
C.elegans  phosphoproteomics  itraq  natural aging  accelerated aging 
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