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TranscriptomicsCleavage of NIK by the API2-MALT1 Fusion Oncoprotein Leads to Noncanonical NF-{kappa}B Activation
Proper regulation of nuclear factor κB (NF-κB) transcriptional activity is required for normal lymphocyte function, and deregulated NF-κB signaling can facilitate lymphomagenesis. We demonstrate that the API2-MALT1 fusion oncoprotein created by the recurrent t(11;18)(q21;q21) in mucosa-associated ly...
ORGANISM(S): Homo sapiens 
2011-01-30 | E-GEOD-25527 | biostudies-arrayexpress
ProteomicsNIK expression stimulated G6PD phosphorylation
Our findings establish NIK as a pivotal regulator of T cell metabolism in anti-tumor immunity and highlight a posttranslational mechanism of metabolic regulation involving the G6PD-NADPH redox system. CoIP assays revealed a strong physical interaction between NIK and G6PD in both T cells and transie...
ORGANISM(S): Homo sapiens (Human) 
2020-10-05 | PXD020943 | Pride
Nik G6pd Phosphoralytion 
ProteomicsPosttranslation modification of NF-kB inducing kinase
2 This project is to identify the potential neddylation sites in human NF-kB inducing kinase (A.k.a. Map3K14). NIK-HA or NIK-HA in combination with FLAG-NEDD8 were co-expressed in HEK293T cells. NIK-HA were pulled down via denaturing immunoprecipitation protocol, subject to SDS-PAGE, in-gel trypsin ...
ORGANISM(S): Homo sapiens (Human) 
2023-03-10 | PXD038653 | Pride
Human Nik 
TranscriptomicsConstitutive activation of the receptor-like kinase NIK impairs translation and confers tolerance to begomovirus infection
To generate an efficient defense against begomovirus, we modulated the activity of the immune defense receptor NIK (NSP-Interacting Kinase) in tomato plants; NIK is a virulence target of the begomovirus NSP during infection. Replacing threonine-474 with aspartate (T474D) within the kinase activation...
ORGANISM(S): Solanum lycopersicum 
2013-12-17 | E-GEOD-38028 | biostudies-arrayexpress
GenomicsRNA-seq Analysis of Transcriptomes in β-Gal-overexpressing, NIK-overexpressing, and NIK(KA)-overexpressing αTC1-6 cells
RNA-seq Analysis of Transcriptomes in β-Gal-overexpressing, NIK-overexpressing, and NIK(KA)-overexpressing αTC1-6 cells
PRJNA448031 | ENA
TranscriptomicsGlobal variation of gene expression induced by constitutive activation of the NIK receptor in Arabidopsis
Arabidopsis was transformed with the NIK receptor or the mutant T474D NIK receptor and infected with CaLCuV. The global variation of gene expression was analysed by RNA-seq at 10 days post inoculation and 20 days post inoculation and differential gene expression was determinated in comparison with m...
ORGANISM(S): Arabidopsis thaliana 
2014-04-21 | E-GEOD-56922 | biostudies-arrayexpress
GenomicsRNA-seq analysis of mRNA profiles in β-Gal-overexpressing, NIK-overexpressing, and NIK(KA)-overexpressing INS-1 832/13 cells
RNA-seq analysis of mRNA profiles in β-Gal-overexpressing, NIK-overexpressing, and NIK(KA)-overexpressing INS-1 832/13 cells
PRJNA534032 | ENA
TranscriptomicsComparasion between MCF7-NIK overexpressing cells, MCF7-control cells and MCF7-NIK depleted cells
Analysis of differentially expressed genes in MCF7 cancer cells transfected with an expression vector containing the ORF of NIK, a shRNA of NIK and a control shRNA. Transient transfections were performed in triplicates . We use micorarrays to elucidate the machanisms by which NIK regulates stem cell...
ORGANISM(S): Homo sapiens 
2015-11-30 | GSE63382 | GEO
UnknownCatalytic subunits of the phosphatase calcineurin interact with NF-κB-inducing kinase (NIK) and attenuate NIK-dependent gene expression.
Not available
S-EPMC5377069 | biostudies-literature
TranscriptomicsRNA-seq Analysis of Transcriptomes in β-Gal-overexpressing, NIK-overexpressing, and NIK(KA)-overexpressing αTC1-6 cells
Purpose: The goal of this study is to determine the molecular mechanisms involved in the NIK regulation of α cell function. Methods: mRNA profiles of β-Gal control, NIK, and NIK(KA) overexpressed αTC1-6 cells were generated by deep sequencing using an Illumina Hiseq platform. Paired-end clean reads ...
ORGANISM(S): Mus musculus 
2018-12-30 | GSE112511 | GEO
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