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ProteomicsA binding site hotspot map of the FKBP12–rapamycin–FRB ternary complex by photo-affinity labeling and mass spectrometry-based proteomics
Structural characterization of small molecule binding site hotspots within the global proteome is uniquely enabled by photo-affinity labeling (PAL) coupled with chemical enrichment and unbiased analysis by mass spectrometry (MS). MS-based binding site hotspot maps provide structural resolution of in...
ORGANISM(S): Homo sapiens (Human) 
2019-07-17 | PXD014319 | Pride
Photo-affinity labeling Structural protemics 
ProteomicsA binding site hotspot map of the FKBP12–rapamycin–FRB ternary complex by photo-affinity labeling and mass spectrometry-based proteomics
PRIDE > Archive > PXD013420 Project PXD013420 Download Project Files Summary Title A binding site hotspot map of the FKBP12–rapamycin–FRB ternary complex by photo-affinity labeling and mass spectrometry-based proteomics Description Structural characterization of small molecule binding site hotspo...
ORGANISM(S): Homo sapiens (Human) 
2024-01-04 | PXD014283 | Pride
Photo-affinity labeling Structural proteomics 
ProteomicsPhoto-affinity labeling with photo-sanglifehrin A probes
The interactome of 2 photo-Sanglifehrin A (pSfA) probes in Jurkat and K562 cells was profiled.
ORGANISM(S): Homo sapiens (Human) 
2024-10-17 | PXD029540 | Pride
Natural product Photo-affinity labeling 
ProteomicsA binding site hotspot map of the FKBP12–rapamycin–FRB ternary complex by photo-affinity labeling and mass spectrometry-based proteomics
Structural characterization of small molecule binding site hotspots within the global proteome is uniquely enabled by photo-affinity labeling (PAL) coupled with chemical enrichment and unbiased analysis by mass spectrometry (MS). MS-based binding site hotspot maps provide structural resolution of in...
ORGANISM(S): Homo sapiens (Human) 
2024-01-04 | PXD013420 | Pride
Photo-affinity labeling Natural product Structural proteomics 
UnknownPhoto-induced defluorination acyl fluoride exchange as a fluorogenic photo-click reaction for photo-affinity labeling.
Not available
S-EPMC10056068 | biostudies-literature
ProteomicsA Cell-Permeable Photosensitizer for Selective Proximity Labeling and Crosslinking of Aggregated Proteome
Intracellular proteome aggregation is a ubiquitous disease hallmark with its composition associated with pathogenicity. Herein, we report on a cell-permeable photosensitizer (P8, Rose Bengal derivative) for selective photo-induced proximity labeling, crosslinking and identification of cellular aggre...
ORGANISM(S): Homo Sapiens 
2023-08-30 | PXD044948 |
UnknownMultiple neurosteroid and cholesterol binding sites in voltage-dependent anion channel-1 determined by photo-affinity labeling.
Not available
S-EPMC6681461 | biostudies-literature
Genomics
Mapping ataluren binding sites on eukaryotic rRNA by photo affinity labeling and RNA-seq
PRJNA714648 | ENA
UnknownPhoto-affinity labelling and biochemical analyses identify the target of trypanocidal simplified natural product analogues.
Not available
S-EPMC5608556 | biostudies-literature
ProteomicsIntracellular targets of the opioids
Opioids are powerful analgesics but carry many contingencies that can lead to opioid-use disorder. Significant energy has been invested in understanding the molecular actions of the opioid alkaloids, particularly their relationship with the opioid receptors at the cell surface. However, there is gro...
ORGANISM(S): Homo sapiens (Human) 
2024-05-07 | PXD045676 | Pride
Heroin Morphine Opioids Lc-ms/ms 
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