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ProteomicsQuantitative thiol reactivity profiling
Cysteine is unique among all protein-coding amino acids owing to its intrinsically high nucleophilicity. The cysteinyl thiol group can be covalently modified by both a broad range of redox mechanisms and various electrophiles derived from exogenous or endogenous sources. Measuring proteomic cysteine...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2020-07-24 | PXD016048 | Pride
Thiol Redox Chemical proteomics Electrophile 
ProteomicsIdentification of the proteins involved in the uptake of coenzyme Q
Ubiquinone (UQ), also known as “coenzyme Q” is an essential player in the mitochondrial respiratory electron transport chain as well as a lipid-soluble antioxidant in eukaryotic cells. In this study, we attempted to identify the proteins involved in the pathway by which the exogenous UQ is taken up ...
ORGANISM(S): Saccharomyces Cerevisiae (baker's Yeast) 
2024-06-25 | PXD049194 | JPOST Repository
UnknownA Benzil- and BODIPY-Based Turn-On Fluorescent Probe for Detection of Hydrogen Peroxide.
Not available
S-EPMC10780145 | biostudies-literature
ProteomicsA whole proteome inventory of background photocrosslinker binding
Affinity based protein profiling (AfBPP) is a widely applied methodology for target identification of bioactive molecules. Photocrosslinkers such as benzophenone, diazirine and aryl azide irreversibly link the molecule of interest to its dedicated target protein upon irradiation with UV light. Despi...
ORGANISM(S): Homo sapiens (Human) 
2016-12-05 | PXD004009 | Pride
Affinity-based protein profiling Photocrosslinker Target identification 
ProteomicsA photo-oxidation driven proximity labeling strategy enables profiling of mitochondrial proteome dynamics in living cells
We herein report a photo-oxidation driven proximity labeling strategy to profile mitochondrial proteome by light dependence in living cells with high spatiotemporal resolution. Taking advantage of organelle-localizable organic photoactivated probe generating reactive species and nucleophilic substra...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD036630 | Pride
Photo-oxidation Proximity labeling Mitochondrial proteome 
UnknownUridine-Modified Ruthenium(II) Complex as Lysosomal LIMP-2 Targeting Photodynamic Therapy Photosensitizer for the Treatment of Triple-Negative Breast Cancer.
Not available
S-EPMC10976599 | biostudies-literature
ProteomicsChemical tools to expand the ligandable proteome: elaborated fragment-based photoreactive stereoprobes
Efforts to expand the ligandable proteome have explored stereochemically defined fragments equipped with photoreactive and clickable handles (photo-stereoprobes) for mapping reversible small molecule-protein interactions in living systems. Here, we investigate the impact of structural elaboration of...
ORGANISM(S): Homo sapiens (Human) 
2024-05-31 | PXD052692 | Pride
Proteomics Chemical biology 
ProteomicsHarnessing BODIPY Carbocation Intermediate for Rapid Protein Proximity Modification
The attractive photo-decaging chemistries of boron-dipyrromethene (BODIPY) chromophores have been well-established with diverse photochemical applications. This work, however, discovers that meso-substituted BODIPY chromophores can modify proteins in proximity via photo-decaging into hyper-reactive ...
ORGANISM(S): Mus Musculus 
2026-07-07 | PXD080664 |
ProteomicsOgasawara et al_photo-stereoprobes
Chemical proteomics enables the global assessment of small molecule-protein interactions in native biological systems and has emerged as a versatile approach for ligand discovery. The range of small molecules explored by chemical proteomics has, however, been limited. Here, we describe a diversity-o...
ORGANISM(S): Homo sapiens (Human) 
2024-05-31 | PXD050096 | Pride
Proteomics Diazirine Chemical biology Photo-reactive probe Phenotypic screening 
TranscriptomicsHeterologous microarrays for the study of drought stress in Musa
'Systems-wide' approaches such as microarray RNA-profiling are ideally suited to the study of the complex, overlapping responses of plants to biotic and abiotic stresses. However, commercial microarrays are only available for a limited number of plant species and development costs are so substantial...
ORGANISM(S): Musa sp. 
2009-07-04 | E-GEOD-16865 | biostudies-arrayexpress
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