Photo-stereoprobes

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Chemical tools to expand the ligandable proteome: elaborated fragment-based photoreactive stereoprobes

Efforts to expand the ligandable proteome have explored stereochemically defined fragments equipped with photoreactive and clickable handles (photo-stereoprobes) for mapping reversible small molecule-protein interactions in living systems. Here, we investigate the impact of structural elaboration of...

ORGANISM(S): Homo sapiens (Human)

2024-05-31 | PXD052692 | Pride

Proteomics Chemical biology

Integrated phenotypic screening and chemical proteomics identifies ETF1 ligands that modulate viral translation and replication

Emerging and re-emerging viruses pose a significant threat to global health. Although direct-acting antivirals have shown success, their efficacy is limited by the rapid emergence of drug-resistant viral variants. Hence, there is an urgent need for additional broad spectrum antiviral therapeutic str...

ORGANISM(S): Severe acute respiratory syndrome coronavirus 2 Homo sapiens (Human) Alphavirus Influenza A virus Mammarenavirus

2026-01-29 | PXD067975 | Pride

Ribosomal frameshifting Photo-stereoprobes Activity-based profiling Virus Sars-cov-2

Ogasawara et al_photo-stereoprobes

Chemical proteomics enables the global assessment of small molecule-protein interactions in native biological systems and has emerged as a versatile approach for ligand discovery. The range of small molecules explored by chemical proteomics has, however, been limited. Here, we describe a diversity-o...