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MetabolomicsTrans-tissue molecular coordination in high-intensity physical activity
High-intensity physical activity has major impacts in different parts of the body. However, the regulatory coordination between different tissues to support the high physical demands is poorly understood. Here we performed a multi-omics analysis of blood plasma, urine and saliva from a group of fire...
2025-07-03 | MTBLS1891 | MetaboLights
MetabolomicsPhysiological and Molecular Dissection of Daily Variance in Exercise Capacity
Physical performance relies on the concerted action of myriad responses, many of which are under circadian clock control. Little is known, however, regarding the time-dependent effect on exercise performance at the molecular level. We found that both mice and humans exhibit daytime variance in exerc...
2019-04-07 | MTBLS145 | MetaboLights
ProteomicsImpact of a tailored exercise regimen on physical capacity, systemic oxidative stress and plasma proteomic profile in PCC patients
Individuals affected by post-covid condition (PCC) show an increased fatigue and the so-called post-exertion malaise (PEM) that led health professionals to advise against exercise although accumulating evidence indicate the contrary. The goal of this study is to determine the impact of a closely mon...
ORGANISM(S): Homo sapiens (Human) 
2024-10-17 | PXD047623 | Pride
Physical activity Exercise Physical capacity Plasma proteomics Fatigue Symptoms Long covid Post covid-19 condition Oxidative stress 
TranscriptomicsTranscription profiling of mouse time series of diabetes and exercise training induced expression changes in skeletal muscle
Experiment protocol: Experiment was performed on 10 to 15 weeks old male NMRI mice (Harlan, Holland) housed in standard conditions (temperature 22°C, humidity 60 ± 10 %, artificial light from 8.00 am to 8.00 pm, normally 5 animals per cage). Animals had free access to tap water and food pellets (R36...
ORGANISM(S): Mus musculus 
2007-10-24 | E-GEOD-1659 | biostudies-arrayexpress
ProteomicsA microbiome-dependent gut brain pathway regulates motivation for exercise
Exercise exerts a wide range of beneficial effects for healthy physiology. However, the mechanisms regulating an individual's motivation to engage in physical activity remain incompletely understood. An important factor stimulating the engagement in both competitive and recreational exercise is the ...
ORGANISM(S): Mouse 
2023-03-15 | MSV000091494 | MassIVE
TranscriptomicsGene expression changes in Peripheral Blood Mononuclear cells (PBMC) induced by physical activity
Gene expression changes in Peripheral Blood Mononuclear cells (PBMC) induced by physical activity was investigated in sedentary middle-aged men (mean age 52.6 years and BMI 29.1) who undertook a 24-week physical activity programme with blood sampling in the pre-exercise period , at the end of 24-w...
ORGANISM(S): Homo sapiens 
2010-08-03 | E-GEOD-12385 | biostudies-arrayexpress
Metabolomics1H NMR Urinary Metabolomic Analysis in Older Adults after Hip Fracture Surgery May Provide Valuable Information for Patient Profiling-A Preliminary Investigation
In these times of precision and personalized medicine, profiling patients to identify their needs is crucial to providing the best and most cost-effective treatment. In this study, we used urine metabolomics to explore the characterization of older adults with hip fractures and to explore the foreca...
2022-10-31 | MTBLS2903 | MetaboLights
TranscriptomicsEffect of IL6 level on gene expression changes in Peripheral Blood Mononuclear cells (PBMC) induced by physical activity
A number of chronic, age-related diseases are associated with elevated markers of inflammation such as interleukin-6 (IL-6). In this study, we investigated the hypothesis that sedentary individuals with disparate basal serum IL-6 respond differentially to a structured physical activity programme. Ge...
ORGANISM(S): Homo sapiens 
2010-08-03 | E-GEOD-12384 | biostudies-arrayexpress
ModelsKoenig2012 - Hepatic Glucose Metabolism
Quantifying the Contribution of the Liver to Glucose Homeostasis: A Detailed Kinetic Model of Human Hepatic Glucose Metabolism Kinetic Model of Human Hepatic Glucose Metabolism Authors Matthias Koenig, Sasc...
2005-01-01 | MODEL1204270001 | BioModels
GenomicsTranscriptome Alterations Associated with Age-Related Decline in Physical Function
Transcriptome Alterations Associated with Age-Related Decline in Physical Function
PRJNA638391 | ENA
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