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MetabolomicsTargeting PI3K inhibitor resistance in breast cancer with metabolic drugs

Activating PIK3CA mutations, present in up to 40% of hormone receptor-positive (HR+), human epidermal growth factor receptor 2-negative (Her2-) breast cancer (BC) patients, can be effectively targeted with the alpha isoform-specific PI3K inhibitor Alpelisib. This treatment significantly improves ...

2026-08-21 | MTBLS11671 | MetaboLights
MetabolomicsMicrobiome Metabolism of Dietary Phytochemicals Controls the Anticancer Activity of PI3K Inhibitors
Phosphatidylinositol 3-kinase (PI3K) signaling is both the effector pathway of insulin and among the most frequently activated pathways in human cancer. In murine cancer models, the efficacy of PI3K inhibitors is dramatically enhanced by a ketogenic diet, with a proposed mechanism involving dietary ...
2025-03-26 | MTBLS10944 | MetaboLights
MetabolomicsSynergistic Effects of High-Fiber Diet and N-Carbamylglutamate on Sow Reproductive Performance via Uterine Microbiota-PI3K/Akt Modulation

Uterine microbiome is crucial for embryo implantation and pregnancy by creating a favorable environment. While both high fiber diet and N-Carbamylglutamate (NCG) have been individually demonstrated to enhance reproductive efficiency in sows, their potential synergistic effects and the involvement...

2026-01-08 | MTBLS13635 | MetaboLights
MetabolomicsSynergistic Effects of High-Fiber Diet and N-Carbamylglutamate on Sow Reproductive Performance via Uterine Microbiota-PI3K/Akt Modulation

Uterine microbiome is crucial for embryo implantation and pregnancy by creating a favorable environment. While both high fiber diet and N-Carbamylglutamate (NCG) have been individually demonstrated to enhance reproductive efficiency in sows, their potential synergistic effects and the involvemen...

2026-01-07 | MTBLS13627 | MetaboLights
MetabolomicsIntegrated multi-omics analysis and experimental verification reveal the involvement of the PI3K/Akt signaling pathway in myometrial fibrosis of adenomyosis.

This analysis established comprehensive metabolomic profiles of adenomyosis patients and revealed widespread alterations in the metabolome within normal and fibrotic myometrium. Integrated analysis shown significant associations between metabolomic data and fibrosis . This study is the first to d...

2025-05-12 | MTBLS11965 | MetaboLights
TranscriptomicsExpression data of one-week-old rice seedlings exposed to Pi-deficient solution for 6, 24, 48, 72 hours
Expression profiles of one-week-old rice seedlings exposed to Pi-deficient solution for 6, 24, 48, 72 hours were monitored by microarray that contains approximately 60,000 rice clones (Affymetrix GeneChip). The probes were prepared from RNAs isolated from rice seedlings exposed to Pi-deficient solut...
ORGANISM(S): Oryza sativa Japonica Group 
2012-06-17 | E-GEOD-35984 | biostudies-arrayexpress
MetabolomicsDietary High Fiber and N-Carbamylglutamate Enhance Sow Reproductive Performance via Modulating Lactobacilli, Lipid Metabolites, and the PI3K-Akt Signaling Pathway

Background Both high fiber diet and N-Carbamylglutamate (NCG) individually contributes to improve reproductive efficiency in sow. However, the potential synergistic effects and the underlying mechanisms are not well-understood. Here, Landrace x Yorkshire sows were selected to investigate the syne...

2025-12-16 | MTBLS13516 | MetaboLights
MetabolomicsXiaoyukang Capsules Promote Hematoma Absorption and Alleviate Neuronal Apoptosis via the Sema3A/NRP1-PI3K/AKT Signaling Axis in Rats with Intracerebral Hemorrhage

This study aimed to clarify the pharmacodynamic material basis and molecular mechanisms of Xiaoyukang Capsules (XYKC) in facilitating hematoma absorption and alleviating secondary nerve injury after intracerebral hemorrhage (ICH), and to identify its core therapeutic targets. Methods An ICH rat m...

2026-07-12 | MTBLS15015 | MetaboLights
TranscriptomicsTranscription profiling of Arabidopsis leaves, roots and whole plants grown in high or low phosphate conditions for different lengths of time
The effects of phosphate starvation in Arabidopsis thaliana (L.) plants were compared in plants grown in liquid MS medium transferred in low or high Pi and in plants grown vertically in petri dishes during 10 days. In the transfer experiments, 2 treatments were analysed for evaluating the short-(3, ...
ORGANISM(S): Arabidopsis thaliana 
2006-09-01 | E-MEXP-791 | biostudies-arrayexpress
ProteomicsOxidative Cyclization Reagents Reveal Tryptophan Cation-pi interactions
Raw data of the project "Oxidative Cyclization Reagents Reveal Tryptophan Cation-pi interactions"
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2024-01-18 | MSV000093891 | MassIVE
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