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ProteomicsSystematic Discovery of Pro- and Anti-HIV Host Factors in Primary Human CD4+ T Cells
Despite extensive efforts, significant gaps remain in our understanding of which host factors promote or restrict human immunodeficiency virus (HIV) infection in human CD4+ T cells. Here, we employed orthogonal genome-wide CRISPR activation (CRISPRa) and CRISPR knockout (CRISPRn) screens in primary ...
ORGANISM(S): Homo sapiens (Human) 
2026-04-27 | PXD071892 | Pride
Host factor Ip-ms Ppi Pi16 Hiv Cd4+ t cells 
UnknownThe fibroblast-derived protein PI16 controls neuropathic pain.
Not available
S-EPMC7071920 | biostudies-literature
UnknownFibroblast-derived PI16 enhances tumor immune-suppressive microenvironment via inducing Tregs differentiation.
Not available
S-EPMC12528301 | biostudies-literature
UnknownPI16 attenuates response to sorafenib and represents a predictive biomarker in hepatocellular carcinoma.
Not available
S-EPMC7541153 | biostudies-literature
UnknownPI16 is a shear stress and inflammation-regulated inhibitor of MMP2.
Not available
S-EPMC5171773 | biostudies-literature
UnknownFibroblasts in metastatic lymph nodes confer cisplatin resistance to ESCC tumor cells via PI16.
Not available
S-EPMC10620422 | biostudies-literature
UnknownPeptidase inhibitor (PI16) impairs bladder cancer metastasis by inhibiting NF-κB activation via disrupting multiple-site ubiquitination of NEMO.
Not available
S-EPMC10388466 | biostudies-literature
UnknownPI16+ reticular cells in human palatine tonsils govern T cell activity in distinct subepithelial niches.
Not available
S-EPMC10307632 | biostudies-literature
GenomicsThe embryonic origins of site-specific arthritis Bulk RNA sequencing of CD34+(Pi16+) fibroblasts stimulated with TNF and IL1b.
The embryonic origins of site-specific arthritis Bulk RNA sequencing of CD34+(Pi16+) fibroblasts stimulated with TNF and IL1b.
PRJNA1457067 | ENA
TranscriptomicsThe embryonic origins of site-specific arthritis; Bulk RNA sequencing of CD34+(Pi16+) fibroblasts stimulated with TNF and IL1b.
The cellular basis for site-specific inflammation remains unclear. In human fingers, proximal interphalangeal (PIP) joints are preferentially affected by inflammatory arthritis, whereas distal interphalangeal (DIP) joints are spared, providing a model to investigate the predilection of inflammation ...
ORGANISM(S): Homo sapiens 
2026-04-28 | GSE328951 | GEO
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