Pi3k/akt/mtor - OmicsDI

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Aerococcus urinae NBRC 15544 = CCUG 36881 (55)
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Homo sapiens (187)
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Mass Spectrometry (55)
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Instrument Platform

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UNIPROT ID/AC

Q13153 (1)
P78527 (1)
P49137 (1)
P49815 (1)
Q92574 (1)
P23443 (1)
P42336 (1)
P35568 (1)
P01308 (1)
Q96B36 (1)
P42345 (1)
P06213 (1)
P27986 (1)
Q13315 (1)
P31749 (1)

CHEBI ID

CHEBI:30769 (3)
CHEBI:24996 (2)
CHEBI:13389 (2)
CHEBI:25523 (2)
CHEBI:48153 (2)
CHEBI:17138 (2)
CHEBI:15422 (2)
CHEBI:16908 (2)
CHEBI:16761 (2)
CHEBI:17665 (2)
CHEBI:15721 (2)
CHEBI:18117 (1)
CHEBI:16464 (1)
CHEBI:40595 (1)
CHEBI:58273 (1)
CHEBI:17050 (1)
CHEBI:26689 (1)
CHEBI:58121 (1)
CHEBI:57737 (1)
CHEBI:17234 (1)
CHEBI:15946 (1)
CHEBI:57642 (1)
CHEBI:16526 (1)
CHEBI:16027 (1)
CHEBI:16077 (1)
CHEBI:18021 (1)
CHEBI:28087 (1)
CHEBI:16938 (1)
CHEBI:18367 (1)
CHEBI:15361 (1)

Metabolite Name

Guanosine (4)
Thymidine (4)
Equol (3)
Hydroquinone (3)
Allantoin (3)
Taurine (3)
Xanthosine (3)
Porphobilinogen (3)
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Uridine (3)
Inosine (3)
Hypoxanthine (3)
4-Hydroxy-2-Oxoglutaric Acid (2)
Folic acid (2)
2'-Deoxyinosine (2)
N-Acetyl-L-methionine (2)
Imidazoleacetic acid (2)
IMP (2)
CAMP (2)
ATP (2)
Corticosterone (2)
Betaine (2)
Deoxyribose 5-Phosphate (2)
N-Acetyl-L-Glutamic Acid (2)
Citramalic Acid (2)
2,6-Dihydroxypurine (2)
Adipic Acid (2)
N-Acetyl-D-Tryptophan (2)
2-Methylsuccinic Acid (2)

IsPrivate

False (3)

First Public Date

2026 (73)
2025 (64)
2024 (52)
2022 (43)
2023 (31)
2021 (29)
2014 (19)
2020 (14)
2019 (10)
2018 (10)
2015 (10)
2017 (7)
2016 (5)

Modelling Approach

Ordinary differential equation model (2)
Boolean model (1)

Study type

Transcription profiling by array (41)
RNA-seq of coding RNA (5)
Human - One-color microarray (1)
Genotyping by array (1)
Comparative genomic hybridization by array (1)
Methylation profiling by array (1)
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RNA-seq of coding RNA from single cells (1)
RNA-seq of non coding RNA (1)

Release Date

2022 (493)
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2021 (427)
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2007 (6)
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2005 (2)
2004 (1)

Lab affiliation

Professor at Department of Pharmacy, Drug Delivery, Uppsala University (4)
1. Division of Experimental Medicine, McGill University, Montreal, QC 2. Segal Cancer Proteomics Centre, Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, QC 3. Department of Pathology, Segal Cancer Centre, Lady Davis Institute for Medical Research, Jewish General Hospital, McGill University, Montreal, QC 4. Segal Cancer Centre, Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, QC 5. Department of Oncology, McGill University, Montreal, QC (1)
2 Yuanmingyuan West Road, Haidian District, Beijing, P.R. China 100193Yuanmingyuan West Road, Haidian District, Beijing, P.R. China 100193 (1)
Barts Cancer Institute (1)
Biological Mass Spectrometry Lab, Department of Translational Medicine (DiMeT), Center for Translational Research on Autoimmune & Allergic Diseases - CAAD - University of Piemonte Orientale, Corso Trieste 15/A, 28100, Novara, Italy (1)
Biomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands (1)
Cancer Program, QIMR Berghofer Medical Research Institute, Brisbane, QLD 4006, Australia (1)
Centre de Recherches en Cancérologie de Toulouse; INSERM U1037, team 17 PI3K isoforms, signalling and cancerogenesis (1)
Centre for Clinical Proteomics, Odense University Hospital, Sdr Boulevard 29, DK-5000 Odense C (1)
Chair, Quantitative Proteomics Director, Proteome Center Tuebingen Interfaculty Institute for Cell Biology University of Tuebingen Auf der Morgenstelle 15 72076 Tuebingen Germany (1)
Departamento de Fisiologia e Biofísica, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil. (1)
Department of Biochemistry and Functional Proteomics, Institute of Biology II, Faculty of Biology and BIOSS Centre for Biological Signalling Studies, University of Freiburg, 79104 Freiburg im Breisgau, Germany (1)
Department of Biochemistry and Functional Proteomics, Institute of Biology II, Faculty of Biology and Signalling Research Centres BIOSS and CIBSS, University of Freiburg, 79104 Freiburg im Breisgau, Germany (1)
Department of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA Arkansas Children’s Research Institute, 13 Children’s Way, Little Rock, AR 72202, USA (1)
Department of Biotechnology, Science Campus, Alagappa University, Karaikudi-630003, Tamil Nadu, India (1)
Department of Burns and Reconstructive Surgery, Xiangya Hospital, Central South University, Changsha, Hunan, P.R. China. (1)
Department of Chemistry, Yale University West Campus Chemical Biology Institute (1)
Department of Developmental Pathology, Institute of Pathology, University Hospital Bonn, 53127 Bonn, Germany (1)
Department of Medical Oncology, Harbin Medical University Cancer Hospital, Heilongjiang Cancer Institute, Harbin 150081, Heilongjiang Province, People闁炽儲鐛� Republic of China. (1)
Department of Neurology and Neuroscience Yale University (1)
Department of Neurology and Neuroscience, Yale University (1)
Department of Obstetrics and Gynecology, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai Jiao Tong University School of medicine (1)
Department of molecular and integrative physiology, university of michigan, ann arbor MI 48109 (1)
Faculty of Biochemistry and Molecular Medicine, University of Oulu, Oulu, Finland (1)
Genomic Medicine Institute, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Avenue, NE-50, Cleveland, Ohio 44195, United States. (1)
German cancer research center, Proteomics of stem cells and cancer, B230 (1)
Harbin Medical University Cancer Hospital, Heilongjiang Cancer Institute, Harbin 150081, Heilongjiang Province, People’s Republic of China. (1)
Head of Proteomics Unit Spanish National Cancer Research Centre (CNIO) Address: Melchor Férnandez Almagro, 3. 28029 Madrid. SPAIN (1)
Indiana University School of Medicine, Dept of Pediatrics; Herman B Wells Center for Pediatric Research (1)
Institute of Bioinformatics, 7th floor, Discoverer building, International Tech Park, Bangalore 560 066, India (1)

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PRDM15 is a master regulator of metabolism essential to sustain B-cell lymphomagenesis

PRDM family members are sequence-specific transcriptional regulators involved in cell identity and fate determination and are often dysregulated in cancer. The PRDM15 gene is of particular interest, given its relatively low expression in adult tissues and its overexpression in follicular lymphomas (...

2025-06-16 | MTBLS1639 | MetaboLights

Alcohol intake exacerbates experimental autoimmune prostatitis through activating PI3K/AKT/mTOR pathwaymediated Th1 differentiation

Epidemiological investigations have revealed a significant association between alcohol consumption and chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS). Nevertheless, the potential mechanisms are still inadequately revealed. This research aimed to investigate the impact of alcohol on CP/CP...

ORGANISM(S): Mus musculus (Mouse)

2025-01-08 | PXD059384 | Pride

PI3K/AKT/mTOR Pathway and c-Myc Inhibit Hepatocyte Suspension under Simulated Microgravity

Simulated microgravity, cell suspension, PI3K/AKT/mTOR pathway, c-Myc

PRJEB96909 | ENA

Alt-RPL36 downregulates the PI3K-AKT-mTOR signaling pathway by interacting with TMEM24

While thousands of previously unannotated small and alternative open reading frames (alt-ORFs) have recently been revealed in the human genome, the functions of only a handful are currently known, leaving open the question of their biological significance as a class. Using a proteomic strategy for d...

ORGANISM(S): Homo sapiens (Human)

2020-12-07 | PXD018268 | Pride

Human microprotein alt-protein phosphoproteomics

MUC3A promotes the progression of colorectal cancer through the PI3K/Akt/mTOR pathway

PRJNA828438 | ENA

AKT antagonist AZD5363 influences estrogen receptor function in endocrine resistant breast cancer and synergizes with fulvestrant (ICI182780) in vivo

Phosphoinositide-3-kinase/protein-kinaseB/mammalian target of rapamycin (PI3K/AKT/mTOR) signalling plays an important role in breast cancer (BC). Its interaction with estrogen receptor (ER) signalling becomes more complex and inter-dependent with acquired endocrine resistance. Targeting mTOR combine...

ORGANISM(S): Homo sapiens

2015-06-29 | E-GEOD-69893 | biostudies-arrayexpress

Ferritin aggregation: A neotype and universal engager for CAR T cell avidity engineering against diverse refractory leukemias

Introduction: Primary liver cancer remains the third leading cause of global cancer-related mortality, with hepatocellular carcinoma (HCC) constituting the predominant histological subtype. The development of malignant ascites in advanced HCC patients signifies metastatic progression and portends...

2025-12-24 | MTBLS13569 | MetaboLights

Optimized isolation of protein on chromatin (iPOC) strategy reveals the dynamics of chromatin composition upon inhibition of PI3K/AKT/mTOR signaling

Signaling pathways play critical roles in executing and controlling important biological processes within cells. The dysregulation of signaling pathways modulates chromatin modifications to regulate the epigenome, thereby contributing to tumorigenesis and metastasis Despite their cancer-related impo...

ORGANISM(S): Homo sapiens (Human)

2025-05-06 | PXD045235 | Pride

Pi3k/akt/mtor Lc/ms-ms Dna binding proteomics

Inhibition of PIK3CA by miR-203a-3p reduces hypertrophic scar formation via PI3K/AKT/mTOR signaling pathway

PRJNA993252 | ENA

Omics analyses of a somatic Trp53R245W/+ breast cancer model identify cooperating driver events activating PI3K/Akt/mTOR signaling

PRJNA856307 | ENA

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