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ProteomicsOptimized isolation of protein on chromatin (iPOC) strategy reveals the dynamics of chromatin composition upon inhibition of PI3K/AKT/mTOR signaling
Signaling pathways play critical roles in executing and controlling important biological processes within cells. The dysregulation of signaling pathways modulates chromatin modifications to regulate the epigenome, thereby contributing to tumorigenesis and metastasis Despite their cancer-related impo...
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD045235 | Pride
Pi3k/akt/mtor Lc/ms-ms Dna binding proteomics 
MetabolomicsFerritin aggregation: A neotype and universal engager for CAR T cell avidity engineering against diverse refractory leukemias

Introduction: Primary liver cancer remains the third leading cause of global cancer-related mortality, with hepatocellular carcinoma (HCC) constituting the predominant histological subtype. The development of malignant ascites in advanced HCC patients signifies metastatic progression and portends...

2025-12-24 | MTBLS13569 | MetaboLights
GenomicsMUC3A promotes the progression of colorectal cancer through the PI3K/Akt/mTOR pathway
MUC3A promotes the progression of colorectal cancer through the PI3K/Akt/mTOR pathway
PRJNA828438 | ENA
UnknownPI3K/AKT/mTOR signaling transduction pathway and targeted therapies in cancer.
Not available
S-EPMC10436543 | biostudies-literature
GenomicsOmics analyses of a somatic Trp53R245W/+ breast cancer model identify cooperating driver events activating PI3K/Akt/mTOR signaling
Omics analyses of a somatic Trp53R245W/+ breast cancer model identify cooperating driver events activating PI3K/Akt/mTOR signaling
PRJNA856307 | ENA
UnknownThe PI3K-AKT-mTOR Pathway and Prostate Cancer: At the Crossroads of AR, MAPK, and WNT Signaling.
Not available
S-EPMC7350257 | biostudies-literature
UnknownTargeting PI3K/AKT/mTOR Signaling Pathway in Breast Cancer.
Not available
S-EPMC8304822 | biostudies-literature
UnknownPI3K/Akt/mTOR Signaling Pathway in Blood Malignancies-New Therapeutic Possibilities.
Not available
S-EPMC10648005 | biostudies-literature
UnknownGypenoside-Induced Apoptosis via the PI3K/AKT/mTOR Signaling Pathway in Bladder Cancer.
Not available
S-EPMC8984741 | biostudies-literature
ModelsMosca2012 - Central Carbon Metabolism Regulated by AKT
Mosca2012 - Central Carbon Metabolism Regulated by AKT The role of the PI3K/Akt/PKB signalling pathway in oncogenesis has been extensively investigated and altered expression or mutations of many components of this pathway have been implicated in human cancers. Indeed, expression o...
2024-09-02 | BIOMD0000000426 | BioModels
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