Pi3k-akt-mtor signaling pathway

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Organisms

Homo sapiens (81)
Mus musculus (34)
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Mus (2)
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UNIPROT ID/AC

P27986 (1)
Q13153 (1)
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CHEBI ID

CHEBI:24996 (2)
CHEBI:17138 (2)
CHEBI:48153 (2)
CHEBI:30769 (2)
CHEBI:15721 (2)
CHEBI:17665 (2)
CHEBI:16908 (2)
CHEBI:18117 (1)
CHEBI:16464 (1)
CHEBI:40595 (1)
CHEBI:13389 (1)
CHEBI:17050 (1)
CHEBI:58273 (1)
CHEBI:57737 (1)
CHEBI:58121 (1)
CHEBI:26689 (1)
CHEBI:57642 (1)
CHEBI:25523 (1)
CHEBI:16077 (1)
CHEBI:16938 (1)
CHEBI:16526 (1)
CHEBI:28087 (1)
CHEBI:15946 (1)
CHEBI:15361 (1)
CHEBI:18021 (1)
CHEBI:17234 (1)
CHEBI:16027 (1)
CHEBI:18367 (1)
CHEBI:16761 (1)
CHEBI:15422 (1)

Metabolite Name

Guanosine (3)
Thymidine (3)
(¡À)11(12)-DiHET (2)
Dl-3,4-Dihydroxymandelic Acid (2)
2-(Formylamino)Benzoic Acid (2)
(¡À)18-HEPE (2)
(3-Methoxy-4-hydroxyphenyl)ethylene glycol sulfate (2)
3-Indoleacrylic acid (2)
Folic acid (2)
CAMP (2)
Tyrosol (2)
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2'-Deoxyinosine (2)
N-Acetyl-L-methionine (2)
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2-Methoxyestrone (2)
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L-Ornithine (2)
N6-Succinyl Adenosine (2)
Glu-Gln (2)
4-Hydroxy-2-Oxoglutaric Acid (2)
2-(Dimethylamino)Guanosine (2)
Corticosterone (2)
Betaine (2)
Allantoin (2)
Histamine (2)
Choline (2)

IsPrivate

False (2)

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Modelling Approach

Ordinary differential equation model (2)

Study type

Transcription profiling by array (33)
RNA-seq of coding RNA (4)
Comparative genomic hybridization by array (1)
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RNA-seq of coding RNA from single cells (1)

Release Date

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Lab affiliation

Institute of Tumor Biology University Medical Center Hamburg-Eppendorf Martinistraße 52, 20246 Hamburg, Germany (1)
Head of Proteomics Unit Spanish National Cancer Research Centre (CNIO) Address: Melchor Férnandez Almagro, 3. 28029 Madrid. SPAIN (1)
Department of Developmental Pathology, Institute of Pathology, University Hospital Bonn, 53127 Bonn, Germany (1)
Key Laboratory of Pharmacology of Traditional Chinese Medical Formulae, Ministry of Education, Tianjin University of Traditional Chinese Medicine, 10 Poyanghu Road, Jinghai District,Tianjin 301617, China. (1)
Faculty of Biochemistry and Molecular Medicine, University of Oulu, Oulu, Finland (1)
Biomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands (1)
Program for Cancer and Cell Biology, Department of Human Anatomy, Histology and Embryology, and PKU International Cancer Institute, Peking University Health Science Center, #38 Xue Yuan Road, Beijing 100191, China. (1)
Department of Biochemistry and Functional Proteomics, Institute of Biology II, Faculty of Biology and Signalling Research Centres BIOSS and CIBSS, University of Freiburg, 79104 Freiburg im Breisgau, Germany (1)
The Smidt Heart Institute, Cedars Sinai Medical Center Cedars-Sinai Medical Center 6David Geffen School of Medicine at UCLA (1)
Segal Cancer Proteomics Centre (1)
German cancer research center, Proteomics of stem cells and cancer, B230 (1)
Centre de Recherches en Cancérologie de Toulouse; INSERM U1037, team 17 PI3K isoforms, signalling and cancerogenesis (1)
Proteomics Facility, The Netherlands Cancer Institute, Amsterdam, The Netherlands (1)
University of Arkansas (1)
Genomic Medicine Institute, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Avenue, NE-50, Cleveland, Ohio 44195, United States. (1)
Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology - Hellas (FORTH), 100, Plastira Str., 70013 Heraklion, Crete, Greece. (1)
2 Yuanmingyuan West Road, Haidian District, Beijing, P.R. China 100193Yuanmingyuan West Road, Haidian District, Beijing, P.R. China 100193 (1)
Chair, Quantitative Proteomics Director, Proteome Center Tuebingen Interfaculty Institute for Cell Biology University of Tuebingen Auf der Morgenstelle 15 72076 Tuebingen Germany (1)
Leibniz Institute on Aging Fritz Lipmann Institute (FLI) Beutenbergstr. 11 07745 Jena, Germany (1)
Department of Chemistry, Yale University West Campus Chemical Biology Institute (1)
Zhengzhou University (1)
Moffitt Cancer Center Tampa, FL, USA (1)

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Alt-RPL36 downregulates the PI3K-AKT-mTOR signaling pathway by interacting with TMEM24

While thousands of previously unannotated small and alternative open reading frames (alt-ORFs) have recently been revealed in the human genome, the functions of only a handful are currently known, leaving open the question of their biological significance as a class. Using a proteomic strategy for d...

ORGANISM(S): Homo sapiens (Human)

2020-12-07 | PXD018268 | Pride

Human microprotein alt-protein phosphoproteomics

Ferritin aggregation: A neotype and universal engager for CAR T cell avidity engineering against diverse refractory leukemias

Introduction: Primary liver cancer remains the third leading cause of global cancer-related mortality, with hepatocellular carcinoma (HCC) constituting the predominant histological subtype. The development of malignant ascites in advanced HCC patients signifies metastatic progression and portends...

2025-12-24 | MTBLS13569 | MetaboLights

Optimized isolation of protein on chromatin (iPOC) strategy reveals the dynamics of chromatin composition upon inhibition of PI3K/AKT/mTOR signaling

Signaling pathways play critical roles in executing and controlling important biological processes within cells. The dysregulation of signaling pathways modulates chromatin modifications to regulate the epigenome, thereby contributing to tumorigenesis and metastasis Despite their cancer-related impo...

ORGANISM(S): Homo sapiens (Human)

2025-05-06 | PXD045235 | Pride

Pi3k/akt/mtor Lc/ms-ms Dna binding proteomics

Celastrol induces autophagy and apoptosis of human osteosarcoma cells via downregulation PI3K/Akt/mTOR signaling pathway

PRJNA1433270 | ENA

FOXO3a Is A Major Target Of Inactivation By PI3K/AKT Signaling In Aggressive Neuroblastoma

Neuroblastoma is a pediatric tumor of the peripheral sympathetic nervous system with a highly variable prognosis. Activation of the PI3K/AKT pathway in neuroblastoma is correlated with poor patient prognosis, but the precise downstream effectors mediating this effect have not been determined. Here, ...

ORGANISM(S): Homo sapiens

2013-05-01 | E-GEOD-42762 | biostudies-arrayexpress

MUC3A promotes the progression of colorectal cancer through the PI3K/Akt/mTOR pathway

PRJNA828438 | ENA

Inhibition of PIK3CA by miR-203a-3p reduces hypertrophic scar formation via PI3K/AKT/mTOR signaling pathway

PRJNA993252 | ENA

LC-MS/MS data of Tinospora cordifolia

Tinospora cordifolia has been used for thousands of years to treat various health conditions, including neurodegenerative diseases. The study aimed to elucidate the mechanism of action and protein targets of T. cordifolia in the context of Alzheimers disease through untargeted metabolomics and netwo...

ORGANISM(S): Tinospora Cordifolia (ncbitaxon:285590)

2024-11-04 | MSV000096283 | MassIVE

Targeting the Phosphoinositide 3-Kinase p110-alpha Isoform Impairs Cell Proliferation, Survival and Tumor Growth in Small Cell Lung Cancer

Purpose: The phosphoinositide 3-kinase (PI3K) pathway is fundamental for cell proliferation and survival and is frequently altered and activated in neoplasia, including carcinomas of the lung. In this study we investigated the potential of targeting the catalytic class IA PI3K isoforms in small cell...

ORGANISM(S): Homo sapiens

2012-12-01 | E-GEOD-40564 | biostudies-arrayexpress

PI3K/Akt/mTOR Signaling Pathway in Blood Malignancies-New Therapeutic Possibilities.

Not available

S-EPMC10648005 | biostudies-literature

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