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ProteomicsDPPA2/4 and SUMO E3 ligase PIAS4 opposingly regulate the emergence of 2C-like cells and zygotic transcriptional program
The molecular mechanism controlling the zygotic genome activation (ZGA) in mammals remains poorly understood. The 2C-like cells spontaneously emerging from cultures of mouse embryonic stem cells (ESCs) share some key transcriptional and epigenetic programs with 2-cell stage embryos. By studying the ...
ORGANISM(S): Mus musculus (Mouse) 
2019-03-06 | PXD012925 | Pride
Pias4 dppa2 zga sumoylation 
TranscriptomicsDPPA2/4 and SUMO E3 ligase PIAS4 opposingly regulate the emergence of 2C-like cells and zygotic transcriptional program
The accurate activation of ZGA transcriptome is important for understanding normal embryo development. However, only few factors are found to regulate this process. Here we identified Pias4-Dppa2 axis regulate the activation of ZGA transcriptome, Dppa2 can activate ZGA transcriptome, Pias4 inhibits ...
ORGANISM(S): Mus musculus 
2019-03-05 | GSE127811 | GEO
GenomicsDPPA2/4 and SUMO E3 ligase PIAS4 opposingly regulate the emergence of 2C-like cells and zygotic transcriptional program
DPPA2/4 and SUMO E3 ligase PIAS4 opposingly regulate the emergence of 2C-like cells and zygotic transcriptional program
PRJNA525439 | ENA
UnknownUbiquitin E3 ligase FIEL1 regulates fibrotic lung injury through SUMO-E3 ligase PIAS4.
Not available
S-EPMC4886359 | biostudies-literature
UnknownDynamics of RIF1 SUMOylation is regulated by PIAS4 in the maintenance of Genomic Stability.
Not available
S-EPMC5727183 | biostudies-literature
UnknownDPPA2/4 and SUMO E3 ligase PIAS4 opposingly regulate zygotic transcriptional program.
Not available
S-EPMC6608977 | biostudies-literature
UnknownPIAS4 regulates pluripotency exit and cell fate commitment in porcine embryonic stem cells.
Not available
S-EPMC12327875 | biostudies-literature
UnknownProtein inhibitor of activated STAT 4 (PIAS4) regulates pro-inflammatory transcription in hepatocytes by repressing SIRT1.
Not available
S-EPMC5189995 | biostudies-literature
UnknownSUMOylation machinery protein, PIAS4 role in breast cancer cell proliferation and drug sensitivity.
Not available
S-EPMC12858598 | biostudies-literature
UnknownMammalian SUMO E3-ligases PIAS1 and PIAS4 promote responses to DNA double-strand breaks.
Not available
S-EPMC2904806 | biostudies-literature
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