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TranscriptomicsC9orf72 BAC Transgenic Mice Display Typical Pathologic Features of ALS/FTD
Noncoding expansions of a hexanucleotide repeat (GGGGCC) in the C9orf72 gene are the most common cause of familial amyotrophic lateral sclerosis and frontotemporal dementia. Here we report transgenic mice carrying a bacterial artificial chromosome (BAC) containing the full human C9orf72 gene with ei...
ORGANISM(S): Mus musculus 
2016-02-10 | E-GEOD-77720 | biostudies-arrayexpress
TranscriptomicsInduced pluripotent stem cell models of progranulin-deficient frontotemporal dementia uncover specific reversible neuronal defects.
Multiple FTD patient-specific iPSC lines were generated for the first time, Human neurons of progranulin haploinsufficiency have been established. PGRN S116X neurons are more sensitive to kinase inhibitors-induced cell stress, which can be rescued by ectopic progranulin expression, revealing progran...
ORGANISM(S): Homo sapiens 
2012-10-25 | E-GEOD-40378 | biostudies-arrayexpress
TranscriptomicsEXPRSS: an Illumina based high-throughput expression-profiling method to reveal transcriptional dynamics - III
Background Next Generation Sequencing technologies have facilitated differential gene expression analysis through RNA-seq and Tag-seq methods. RNA-seq has biases associated with transcript lengths, lacks uniform coverage of regions in mRNA and requires 10M-bM-^@M-^S20 times more reads than a typical...
ORGANISM(S): Arabidopsis thaliana 
2014-06-20 | E-GEOD-52596 | biostudies-arrayexpress
UnknownBiographical analysis of 32 pharmacologists persecuted under the Nazi regime: scientific careers between persecution, emigration, and new beginnings.
Not available
S-EPMC12678629 | biostudies-literature
UnknownNanoreporter Identifies Lysosomal Storage Disease Lipid Accumulation Intracranially.
Not available
S-EPMC11246544 | biostudies-literature
TranscriptomicsGlobal gene expression in catfish spleen after injection of lipopolysaccharide
A high-density oligonucleotide microarray for channel catfish (Ictalurus punctatus) was designed and produced with Maskless Array Synthesizer technology (MAS). The microarray contained ~379,652 24-mer oligonucleotides covering ~18,999 catfish unique sequences. The global expression profiling of the ...
ORGANISM(S): Ictalurus punctatus 
2005-11-30 | E-GEOD-3261 | biostudies-arrayexpress
TranscriptomicsThe C-Terminal Domain of RNA Polymerase II is Modified by Site-Specific Methylation
The Carboxy-terminal domain (CTD) of RNA Polymerase II (RNAPII) in mammals undergoes extensive post-translational modification, which is essential for transcriptional initiation and elongation. Here, we show that the CTD of RNAPII is methylated at a single arginine (R1810) by the transcriptional co-...
ORGANISM(S): Homo sapiens 
2011-04-01 | E-GEOD-27315 | biostudies-arrayexpress
TranscriptomicsExpression data from BAP1 depleted cells
The deubiquitinase BAP1 is a candidate tumor suppressor regulating cell proliferation in human and is required for development in Drosophila. BAP1 is assembled into high molecular weight transcriptional multi-protein complexes. In order to identify potential BAP1 target genes, global mRNA expression...
ORGANISM(S): Homo sapiens 
2010-11-05 | E-GEOD-23035 | biostudies-arrayexpress
TranscriptomicsMultiple platform assessment and isomir analysis of the EGF dependent microRNA-ome by microarray and deep sequencing analysis [Agilent]
We have used an integrative high content analysis approach to identify the specific miRNAs implicated in EGF signaling in HeLa cells as potential mediators of cancer mediated functions. We have used microarray and deep-sequencing technologies in order to obtain a global view of the EGF miRNA transcr...
ORGANISM(S): Homo sapiens 
2013-06-11 | E-GEOD-41181 | biostudies-arrayexpress
TranscriptomicsMultiple platform assessment and isomir analysis of the EGF dependent microRNA-ome by microarray and deep sequencing analysis [Exiqon]
We have used an integrative high content analysis approach to identify the specific miRNAs implicated in EGF signaling in HeLa cells as potential mediators of cancer mediated functions. We have used microarray and deep-sequencing technologies in order to obtain a global view of the EGF miRNA transcr...
ORGANISM(S): Homo sapiens 
2013-06-11 | E-GEOD-41225 | biostudies-arrayexpress
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