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TranscriptomicsComparing gene expression between PICs and satellite cells from 1 week old muscle
The satellite cell is considered the major tissue-resident stem cell underlying muscle regeneration, however, multiple non-satellite cell myogenic progenitors have been identified. PW1/Peg3 is expressed in satellite cells as well as a subset of interstitial cells with myogenic potential termed PICs ...
ORGANISM(S): Mus musculus 
2012-09-01 | E-GEOD-40523 | biostudies-arrayexpress
GenomicsFunctional proteomics identified a PICS complex required for piRNA maturation and chromosome segregation
Functional proteomics identified a PICS complex required for piRNA maturation and chromosome segregation
PRJNA540207 | ENA
TranscriptomicsEffect of L-Proline on mouse embryonic stem cells (ESCs)
We found that the non-essential amino acid L-Proline (L-Pro) acts as a signaling molecule that promotes the conversion of embryonic stem cells (ESCs) into mesenchymal-like, spindle-shaped, highly motile, invasive pluripotent stem cells. This embryonic stem cell-to-mesenchymal-like transition (esMT) ...
ORGANISM(S): Mus musculus 
2013-09-05 | E-GEOD-50603 | biostudies-arrayexpress
TranscriptomicsComparing gene expression between PICs and satellite cells from 1 week old muscle
The satellite cell is considered the major tissue-resident stem cell underlying muscle regeneration, however, multiple non-satellite cell myogenic progenitors have been identified. PW1/Peg3 is expressed in satellite cells as well as a subset of interstitial cells with myogenic potential termed PICs ...
ORGANISM(S): Mus musculus 
2012-09-01 | GSE40523 | GEO
ProteomicsAtLEGbeta / gamma protease specificity characterization by PICS
Arabidopsis thaliana Legumain (aka VPE) beta / gamma proteases were characterized for their cleavage specificity by PICS (Proteomic Identification of protease Cleavage Sites).
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) Escherichia coli 
2020-07-29 | PXD019220 | Pride
Arabidopsis legumain beta gamma protease 
GenomicsFunctional proteomics identified a PICS complex required for piRNA maturation and chromosome segregation
Piwi-interacting RNAs (piRNAs) play significant roles in suppressing transposons and nonself nucleic acids, maintaining genome integrity, and defending against viral infections, and are essential for fertility in a variety of organisms. In C. elegans, most piRNA precursors are transcribed by RNA pol...
ORGANISM(S): Caenorhabditis elegans 
2019-05-19 | GSE130371 | GEO
TranscriptomicsFull and partial genome-wide assembly and disassembly of the yeast transcription machinery in response to heat shock
Eukaryotic genes are controlled by sequence-specific DNA-binding proteins, chromatin regulators, general transcription factors, and elongation factors. Here we examine the genome-wide location of representative members of these groups and their redistribution when the Saccharomyces cerevisiae genom...
ORGANISM(S): Saccharomyces cerevisiae 
2010-06-10 | E-GEOD-2488 | biostudies-arrayexpress
ProteomicsLauroylation-assisted workflow for both PICS and N-terminomics
(1) Lauroylation-assisted workflow for PICS using E. coli proteome-derived tryptic peptide libraries which were blocked (succinylation or dimethylation). (2) Lauroylation-assisted N-terminomics to profile protein N-termini, ORF and non-ORF protein N-termini, using etoposide-treated cholangiocarcinom...
ORGANISM(S): Homo Sapiens (human) Escherichia Coli 
2026-05-01 | PXD067596 | JPOST Repository
ProteomicsActive Site Specificity Profiling of the Matrix Metalloproteinase Family: Proteomic Identification of 4,300 Cleavage Sites by MMPs 1, 2, 3, 7, 8, 9, 12, 13, and 14.
Background: The active site of matrix metalloproteinases (MMPs) is highly conserved, complicating the rational design of specific substrates and inhibitors for individual family members. Results: Active site specificity profiles of 9 MMPs were determined using high throughput Proteomic Identificatio...
ORGANISM(S): Homo sapiens (Human) 
2015-09-29 | PXD002265 | Pride
Ecm Pics Mmps Mass spectrometry Specificity profiling Webpics 
UnknownMolecular basis for PICS-mediated piRNA biogenesis and cell division.
Not available
S-EPMC8458385 | biostudies-literature
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