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TranscriptomicsTranscription profiling of mouse striatum treated with morphine, animals from four inbred strains
Chronic opiate use produces molecular and cellular adaptations in the nervous system, leading to tolerance, physical dependence and addiction. Genome-wide comparison of morphine-induced changes in brain transcription of mouse strains with different opioid-related phenotypes provides an opportunity t...
ORGANISM(S): Mus musculus 
2009-02-07 | E-GEOD-7762 | biostudies-arrayexpress
TranscriptomicsTranscriptional effects of chronic heroin and methamphetamine treatment in the mouse striatum
To identify molecular effects of chronic drug treatment, heroin and methamphetamine treated animals were compared with saline treated animals at multiple time-points using microarray technology. Gene expression profile was assessed 14 h after the last dose of 1, 3, 6 or 12 days drug treatment and af...
ORGANISM(S): Mus musculus 
2012-06-20 | E-GEOD-30305 | biostudies-arrayexpress
TranscriptomicsThe comparison of gene expression profile in the amygdalae between the wild-type and neuropsin knock-out mice
Extracellular proteolysis contributes to fear-associated responses by facilitating neuronal plasticity at the neuron-matrix interface. A serine protease neuropsin is critical for stress-related plasticity in the amygdala by regulating the strength of EphB2/NMDA receptor interaction controlling the e...
ORGANISM(S): Mus musculus 
2011-05-13 | E-GEOD-27088 | biostudies-arrayexpress
TranscriptomicsGlobal expression profiling of ruptured and unruptured human intracranial aneurysms
The primary aim of the present study was to identify differences on the transcription level between ruptured and unruptured intracranial aneurysms as well as normal intracranial arteries in human. Keywords: Expression profiling by array Global gene expression profiling was performed in human intrac...
ORGANISM(S): Homo sapiens 
2010-05-08 | E-GEOD-15629 | biostudies-arrayexpress
TranscriptomicsPsychotropic drug-induced gene expression alterations in mouse striatum I
To identify the molecular mechanisms that may initiate therapeutic effects, whole-genome expression profiling (Illumina Mouse WG-6 microarrays) of drug-induced alterations in the mouse brain was undertaken, with a focus on the time-course (1, 2, 4 and 8h) of gene expression changes produced by eight...
ORGANISM(S): Mus musculus 
2013-07-18 | E-GEOD-48951 | biostudies-arrayexpress
TranscriptomicsPsychotropic drug-induced gene expression alterations in mouse striatum II
To identify the molecular mechanisms that may initiate therapeutic effects, whole-genome expression profiling (Illumina Mouse WG-6 microarrays) of drug-induced alterations in the mouse brain was undertaken, with a focus on the time-course (1, 2, 4 and 8h) of gene expression changes produced by eight...
ORGANISM(S): Mus musculus 
2013-07-18 | E-GEOD-48954 | biostudies-arrayexpress
TranscriptomicsMolecular profile of ketamine in comparison to memantine and phencyclidyne and other psychotropic drugs [mouse hippocampus]
Ketamine has been found to elicit a rapid antidepressant effects in treatment-refractory affective disorders. To indicate the underlying mechanism of action we have performed whole-genome microarray profiling. Moreover, the effects of ketamine were compared to other NMDA receptor antagonists phencyc...
ORGANISM(S): Mus musculus 
2015-12-31 | E-GEOD-73798 | biostudies-arrayexpress
TranscriptomicsMolecular profile of ketamine in comparison to memantine and phencyclidyne and other psychotropic drugs [mouse striatum]
Ketamine has been found to elicit a rapid antidepressant effects in treatment-refractory affective disorders. To indicate the underlying mechanism of action we have performed whole-genome microarray profiling. Moreover, the effects of ketamine were compared to other NMDA receptor antagonists phencyc...
ORGANISM(S): Mus musculus 
2015-12-31 | E-GEOD-73799 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human monocyte derived macrophages response to IL-1 and IL-6
Using whole-genome Affymetrix microarrays (HG-U133A), we characterized the transcriptome profile of cultured human macrophages stimulated for 4 h with interleukin 1 (IL-1) or interleukin 6 (IL-6). We found that, in distinction to liver cells, IL-1 is much more potent than IL-6 in modifying macrophag...
ORGANISM(S): Homo sapiens 
2008-06-16 | E-GEOD-8515 | biostudies-arrayexpress
TranscriptomicsStress-induced gene expression alterations in the amygdala of C57BL/6J and SWR/J mice.
Comparison of changes in gene expression between the mouse strains (C57BL/6J and SWR/J) with diverse phenotype provides the possibility to find associations between transcriptional and behavioral response to the stress. We used whole-genome Illumina microarrays to analyze the effects on transcriptio...
ORGANISM(S): Mus musculus 
2015-12-31 | E-GEOD-74002 | biostudies-arrayexpress
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