The comparison of gene expression profile in the amygdalae between the wild-type and neuropsin knock-out mice

ABSTRACT: Extracellular proteolysis contributes to fear-associated responses by facilitating neuronal plasticity at the neuron-matrix interface. A serine protease neuropsin is critical for stress-related plasticity in the amygdala by regulating the strength of EphB2/NMDA receptor interaction controlling the expression of fear-related genes and anxiety-like behavior. To look for downstream effects of neuropsin-mediated disassembly of the EphB2/NR1 complex we analyzed gene expression in the amygdalae of wild-type and neuropsin-/- mice. Wild-type control and neuropsin-/- mice were anaesthetised and perfused transcardially with ice cold PBS. The brains were removed and dissected using a vibrating microtome. Amygdalae were dissected from a coronal slice and were stored in RNAlater until processed. The am

ORGANISM(S): Mus musculus

SUBMITTER: Marcin Piechota 

PROVIDER: E-GEOD-27088 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress