Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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The comparison of gene expression profile in the amygdalae between the wild-type and neuropsin knock-out mice

ABSTRACT: Extracellular proteolysis contributes to fear-associated responses by facilitating neuronal plasticity at the neuron-matrix interface. A serine protease neuropsin is critical for stress-related plasticity in the amygdala by regulating the strength of EphB2/NMDA receptor interaction controlling the expression of fear-related genes and anxiety-like behavior. To look for downstream effects of neuropsin-mediated disassembly of the EphB2/NR1 complex we analyzed gene expression in the amygdalae of wild-type and neuropsin-/- mice. Wild-type control and neuropsin-/- mice were anaesthetised and perfused transcardially with ice cold PBS. The brains were removed and dissected using a vibrating microtome. Amygdalae were dissected from a coronal slice and were stored in RNAlater until processed. The amygdalae have been isolated from 15 brains of neuropsin-/- and 15 wild-type control animals. RNA pulled from 3 animals has been reverse transcribed and hybridized with GeneChip Mouse Exon 1.0 ST Affymetrix Array.

ORGANISM(S): Mus musculus

SUBMITTER: Marcin Piechota 

PROVIDER: E-GEOD-27088 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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A minority of individuals experiencing traumatic events develop anxiety disorders. The reason for the lack of correspondence between the prevalence of exposure to psychological trauma and the development of anxiety is unknown. Extracellular proteolysis contributes to fear-associated responses by facilitating neuronal plasticity at the neuron-matrix interface. Here we show in mice that the serine protease neuropsin is critical for stress-related plasticity in the amygdala by regulating the dynami  ...[more]

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