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TranscriptomicsTranscription profling of infants (<1 year of age) diagnosed with Acute Lymphoblastic Leukemia (ALL) characterised by genomic translocation.
Acute Lymphoblastic Leukemia (ALL) in infants (<1 year) is characterized by a poor prognosis and a high incidence of MLL translocations. Several studies demonstrated the unique gene expression profile associated with MLL-rearranged ALL, but generally small cohorts were analyzed as uniform patient gr...
ORGANISM(S): Homo sapiens 
2009-12-15 | E-GEOD-19475 | biostudies-arrayexpress
TranscriptomicsReversal of glucocorticoid resistance by AKT inhibition in T-ALL
Glucocorticoid resistance is a major driver of therapeutic failure in T-cell acute lymphoblastic leukemia (T-ALL). Here we used a systems biology approach, based on the reverse engineering of signaling regulatory networks, which identified the AKT1 kinase as a signaling factor driving glucocortico...
ORGANISM(S): Homo sapiens 
2013-05-30 | E-GEOD-32215 | biostudies-arrayexpress
TranscriptomicsIntegrated transcript and genome analyses reveal NKX2-1 and MEF2C as potential oncogenes in T-ALL
To identify novel oncogenic pathways in T-cell acute lymphoblastic leukemia (T-ALL), we combined expression profiling of 117 pediatric patient samples and detailed molecular cytogenetic analyses including the Chromosome Conformation Capture on Chip (4C) method. Two T-ALL subtypes were identified tha...
ORGANISM(S): Homo sapiens 
2011-04-11 | E-GEOD-26713 | biostudies-arrayexpress
UnknownInfluence of Cranial Radiotherapy on Outcome in Children With Acute Lymphoblastic Leukemia Treated With Contemporary Therapy.
Not available
S-EPMC4871998 | biostudies-literature
TranscriptomicsTranscription profiling of rat tissues with subchronic Hexachlorobenzene exposure in brown norway wats
Hexachlorobenzene (HCB) [CAS:118-74-1; CHEBI:5692] is a persistent environmental pollutant with toxic effects in man and rat. Reported adverse effects are hepatic porphyria, neurotoxicity, and adverse effects on the reproductive and immune system. To obtain more insight into HCB-induced mechanisms o...
ORGANISM(S): Rattus norvegicus 
2011-11-08 | E-TOXM-15 | biostudies-arrayexpress
UnknownChildhood Acute Lymphoblastic Leukemia: Progress Through Collaboration.
Not available
S-EPMC4567699 | biostudies-literature
UnknownSecond malignant neoplasms after treatment of childhood acute lymphoblastic leukemia.
Not available
S-EPMC3807139 | biostudies-literature
TranscriptomicsGSI, Human T-ALL
The NOTCH signaling cascade, which is deregulated in T-cell acute lymphoblastic leukemia (T-ALL) and many other human cancers, offers an attractive target for molecular therapy. One approach employs gamma-secretase inhibitors (GSIs) to suppress production of the intracellular form of NOTCH (NICD), ...
ORGANISM(S): Homo sapiens 
2010-05-27 | E-GEOD-8416 | biostudies-arrayexpress
TranscriptomicscaArray_EXP-520: Gene Expression Profiles Predictive of Outcome and Age in Infant Acute Lymphoblastic Leukemia: a Children's Oncology Group Study
Gene expression profiling was performed on 97 cases of infant ALL from Children's Oncology Group Trial P9407. Statistical modeling of an outcome predictor revealed 3 genes highly predictive of event-free survival (EFS), beyond age and MLL status: FLT3, IRX2, and TACC2. Low FLT3 expression was found ...
ORGANISM(S): Homo sapiens 
2015-05-12 | E-GEOD-68720 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human CEM_C1 cells after rapamycin treatment of 24 hours
Drug resistance remains a major obstacle to successful cancer treatment. Here we use a novel approach to identify rapamycin as a glucocorticoid resistance reversal agent. A database of drug-associated gene expression profiles was screened for molecules whose profile overlapped with a gene expression...
ORGANISM(S): Homo sapiens 
2008-06-14 | E-GEOD-5821 | biostudies-arrayexpress
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