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GenomicsClonal expansion analysis of transposon insertions by high-throughput sequencing identifies candidate cancer genes in a PiggyBac mutagenesis screen
Somatic transposon mutagenesis in mice is an efficient strategy to investigate the genetic mechanisms of tumorigenesis. The identification of tumor driving transposon insertions traditionally requires the generation of large tumor cohorts to obtain information about common insertion sites. Tumor dri...
ORGANISM(S): Mus musculus 
2013-08-28 | E-GEOD-46210 | biostudies-arrayexpress
ProteomicsIdentification of phosphorylation sites in piggyBac transposase N-terminus
The piggyBac transposon system is widely used for biotechnology and genome engineering and is the founding member of a large superfamily of piggyBac-like elements. We investigated the role in transpositon of the nonconserved N-terminus in the piggyBac transposase, including the impact of predicted c...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD037132 | Pride
Transposition Piggybac 
GenomicsTransposase N-terminal phosphorylation and asymmetric transposon ends inhibit piggyBac transposition in mammalian cells
Transposase N-terminal phosphorylation and asymmetric transposon ends inhibit piggyBac transposition in mammalian cells
PRJNA833459 | ENA
UnknownpiggyBac transposon remobilization and enhancer detection in Anopheles mosquitoes.
Not available
S-EPMC3182679 | biostudies-literature
UnknownManipulating piggyBac transposon chromosomal integration site selection in human cells.
Not available
S-EPMC3182353 | biostudies-literature
GenomicsA PiggyBac transposon screen in pancreatic cancer
A PiggyBac transposon based screen in a murine pancreatic cancer model.This data has been described in the following article [doi:10.1038/ng.3164] and its further analysis can be freely submitted for publication. For information on the proper use of data shared by the Wellcome Trust Sanger Institute...
ORGANISM(S): Mus musculus 
2016-07-04 | E-ERAD-514 | biostudies-arrayexpress
UnknownGeneration of an inducible and optimized piggyBac transposon system.
Not available
S-EPMC1919496 | biostudies-literature
UnknownHybrid nonviral/viral vector systems for improved piggyBac DNA transposon in vivo delivery.
Not available
S-EPMC4395777 | biostudies-literature
OtherTransposase N-terminal phosphorylation and asymmetric transposon ends inhibit piggyBac transposition in mammalian cells
DNA transposon systems are widely used in mammalian cells for genetic modification experiments, but their regulation remains poorly understood. We used biochemical and cell-based assays together with AlphaFold modeling and rational protein redesign to evaluate aspects of piggyBac transposition inclu...
ORGANISM(S): Homo sapiens 
2022-11-10 | GSE201914 | GEO
Transcriptomics"Calling Cards" for DNA-binding proteins in mammalian cells
The ability to chronicle transcription factor binding events throughout the development of an organism would facilitate mapping of transcriptional networks that control cell fate decisions. We describe a method for permanently recording protein-DNA interactions in mammalian cells. We endow transcri...
ORGANISM(S): Homo sapiens 
2011-12-31 | E-GEOD-34791 | biostudies-arrayexpress
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