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ProteomicsIdentification of proteins bound to chromatin of male meiotic cells.
Identification of lactic dehydrogenase C (LDHC)(but not lactic dehydrogenase A -LDHA) presence amoung chromatin bound proteins of pachytene/diplotene/diakinesis (PDD) cells isolated from Stra8-CAG-tdTomato mice testis. LDHC (but not LDHA) was found to be bound to chromosomes and centromeres of PDD c...
ORGANISM(S): Mus musculus (Mouse) 
2025-05-23 | PXD039014 | Pride
Germ cells Spermatogenesis Mice Lc-ms/ms 
ProteomicsWhole cell proteimics of leptotene+zygotene(LZ) and pachytene+diplotene+diakinesis (PDD) of first meiosis prophase of spermatogenesis in male mouse.
2-hydroxyglutarate (2HG) is recognized as an epigenetic regulator in cancer and some transient biological processes. Of all organs, the testis harbors the highest baseline physiological levels of 2HG, yet it’s putative functions in germ cell biology are unknown. Here we show that 2HG is generated in...
ORGANISM(S): Mus musculus (Mouse) 
2025-05-23 | PXD039015 | Pride
Testis Meiosis Spermatogenesis Lc-ms/ms 
TranscriptomicsChronic liver inflammation-induced double strand DNA breaks enhance hepatocarcinogenesis
Surgical resection is the preferred treatment for Hepatocellular carcinoma; however, it induces tumor recurrence. Our objective was to understand the molecular mechanisms linking liver regeneration under chronic-inflammation to tumorigenesis. Mdr2-knockout mice, a model of inflammation-associated ca...
ORGANISM(S): Mus musculus 
2010-01-03 | E-GEOD-14539 | biostudies-arrayexpress
TranscriptomicsAmplicon sequencing of the trp53 locus of DNA extracted from FFPE sections of tumors obtained from the gastrointestinal tract of APC mice
This experiment was done to analyze the p53 status in gastrointestinal tumors in the colon and small intestine in APC mice carrying either a wild type p53 or a mutant p53 (R172H) allele and compare colon and small intestine tumors.
ORGANISM(S): Mus musculus 
2020-02-25 | E-MTAB-8355 | biostudies-arrayexpress
UnknownUVB-Induced Tumor Heterogeneity Diminishes Immune Response in Melanoma.
Not available
S-EPMC6863386 | biostudies-literature
TranscriptomicsIntestinal ablation of CKIalpha highlights invasiveness control
Wnt signaling, which drives the rapid self-renewal of the gut epithelium is causally associated with intestinal neoplasia. Here we show that CKIalpha is a activation depends on p53 and p21Waf1/Cip1: CKIα ablation provokes activation of p53 and p21, which assume a pivotal role in suppressing invasiv...
ORGANISM(S): Mus musculus 
2010-10-23 | E-GEOD-24760 | biostudies-arrayexpress
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