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Comparison of the gene expression of microdissected pancreas ductal adenocarcinoma to microdissected normal duct cells
ORGANISM(S): Homo sapiens 
Gene expression of pancreas ductal adenocarcinoma, normal duct cells, tumor stroma and stroma of chronic pancreatitis as well as of several cell lines. All primary tissue samples were microdissected. It is an addition of the data set E-MEXP-950.
ORGANISM(S): Homo sapiens 
Wiskott-Aldrich syndrome (WAS) predisposes patients to leukemia and lymphoma. WAS is caused by mutations in the protein WASP which impair its interaction with the WIPF1 protein. Here, we aim to identify a module of WIPF1-coexpressed genes and to assess its use as a prognostic signature for colorecta...
ORGANISM(S): Homo sapiens 
Ductal carcinomas and papillary cancers of the pancreas were microdissected and their expression profiles compared.
ORGANISM(S): Homo sapiens 
STAG2 is targeted by somatic aberrations in a subset (4%) of human PDAs. Transposon mediated disruption of STAG2 in a KRASG12D genetically engineered mouse model promotes the development of PDA and its progression to metastatic disease. There was a statistically significant loss of STAG2 protein exp...
ORGANISM(S): Homo sapiens 
Pancreatic cancer remains one of the most lethal of malignancies and a major health burden. We performed whole genome sequencing and CNV analysis of 100 pancreatic ductal adenocarcinomas. Chromosomal rearrangements leading to gene disruption were frequent, affecting genes known to be important in pa...
ORGANISM(S): Homo sapiens 
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