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TranscriptomicsTranscription profiling of mouse NeuroD1 knockout pineal glands vs 129 wild types at P0
This study determines pineal gland gene expression levels in the NeuroD1 knockout mouse at postnatal day zero. Comparison was performed against pineal gland gene expression levels in 129 wildtype mice also disected at P0. Experiment Overall Design: Wildype 129 mice served as the reference in compari...
ORGANISM(S): Mus musculus 
2008-06-14 | E-GEOD-6030 | biostudies-arrayexpress
TranscriptomicsTranscriptome in 129sv and Crx-/- pineal gland at ZT (Zeitgeber time) 6 and ZT20
The cone-rod homeobox gene (Crx) encodes Crx, a transcription factor selectively expressed in two cell types, retinal photoreceptors and the melatonin secreting pinealocytes of the pineal gland. In this report the role of Crx in regulating gene expression in the mammalian pineal gland was extended u...
ORGANISM(S): Mus musculus 
2012-01-01 | E-GEOD-24625 | biostudies-arrayexpress
TranscriptomicsCircadian Transcriptome of the Chicken Pineal In Vitro
Chick pinealocytes exhibit all the characteristics of a complete circadian system, comprising photoreceptive inputs, molecular clockworks and an easily measured rhythmic output, melatonin biosynthesis. We used microarray analysis to investigate the expression of approximately 8000 genes within cult...
ORGANISM(S): Gallus gallus 
2008-07-04 | E-GEOD-5292 | biostudies-arrayexpress
ProteomicsCharacterization of human pineal gland proteome
Pineal gland is a neuroendocrine gland located at the center of the brain. It protects the body from the effect of toxic compounds and regulates sleep-wake cycle, body temperature and sexual maturity through the secretion of melatonin. Abnormal functioning of pineal glands is known to be associat...
ORGANISM(S): Homo sapiens (Human) 
2017-02-02 | PXD004332 | Pride
Human Gland Tissue Pineal Lc-ms/ms 
TranscriptomicsSelective knockout of NeuroD1 in the retina and pineal gland
NeuroD1 encodes a basic helix-loop-helix transcription factor involved in the development of neural and endocrine structures. NeuroD1 mRNA is highly abundant in the adult mammalian pineal gland and exhibits a developmental expression pattern similar to the retina. This is consistent with the common ...
ORGANISM(S): Mus musculus 
2012-07-25 | E-GEOD-35396 | biostudies-arrayexpress
TranscriptomicsTime-of-day-dependent light-induction of gene expression in the chicken pineal gland
Light has a strong effect on whole organism physiology, such as the circadian rhythms that are phase delayed and advanced by light given at early and late subjective night, respectively. Despite the importance of the phase-dependent light responses, little is known about the underlying molecular mec...
ORGANISM(S): Gallus gallus 
2011-03-08 | E-GEOD-21915 | biostudies-arrayexpress
TranscriptomicsWhole transcriptome profiling of the rat pineal gland during development from embryonic day 21 to adult
The transcriptome of the rat pineal gland is highly dynamic, with many hundreds of genes changing more than two-fold on a 24-hr daily rhythm, as revealed earlier using Affymetrix GeneChip analysis. Several key transcription factors and enzymes are known to change dramatically during development of t...
ORGANISM(S): Rattus norvegicus 
2014-10-24 | E-GEOD-46127 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of zebrafish pineal gland
Microarray data allowed detection of genes that are highly expressed in the pineal gland. Experiment Overall Design: Adult Tg(aanat2:EGFP)Y8 transgenic zebrafish in which EGFP marks the pineal gland were used for RNA extraction and hybridization on Affymetrix microarrays. Fish were anesthetized in 1...
ORGANISM(S): Danio rerio 
2009-05-11 | E-GEOD-13196 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of rat pineal Expt C
Biological processes are optimized by circadian and circannual biological timing systems. In vertebrates, the pineal gland plays an essential role in these systems by converting time into a hormonal signal, melatonin; in all vertebrates, circulating melatonin is elevated at night, independent of li...
ORGANISM(S): Rattus norvegicus 
2009-01-27 | E-GEOD-12343 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of rat pineal Expt A
Biological processes are optimized by circadian and circannual biological timing systems. In vertebrates, the pineal gland plays an essential role in these systems by converting time into a hormonal signal, melatonin; in all vertebrates, circulating melatonin is elevated at night, independent of li...
ORGANISM(S): Rattus norvegicus 
2009-01-25 | E-GEOD-12341 | biostudies-arrayexpress
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