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ProteomicsNew molecular mechanisms in cholangiocarcinoma: signals triggering interleukin-6 production in tumor cells and KRAS co-opted epigenetic mediators driving metabolic reprogramming.
Cholangiocarcinoma (CCA) is a deadly tumour lacking effective therapies. Clinically-relevant experimental models and analysis of human samples represent the cornerstone of mechanistic cancer research. Thioacetamide (TAA)-induced intrahepatic CCA (iCCA) in rats encompasses key histological and molecu...
ORGANISM(S): Rattus norvegicus (Rat) 
2022-06-09 | PXD032802 | Pride
Cholangiocarcinoma  bile  inflammation  interleukin-6  kras  g9a histone methyl-transferase  serine-glycine pathway  metabolic reprogramming. 
ProteomicsBiomarkers of Cholangiocarcinoma and Pancreatic adenocarcinoma
Cholangiocarcinoma (CCA) and pancreatic adenocarcinoma (PDAC) may lead to the development of extrahepatic obstructive cholestasis. However, biliary stenoses can also be caused by benign conditions, and the identification of their etiology still remains a clinical challenge. We performed metabolomic ...
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD019924 | Pride
Human bile  cholangiocarcinoma  pancreatic adenocarcinoma  lipidomics  proteomics  machine learning 
UnknownSARS-CoV-2 vaccination modelling for safe surgery to save lives: data from an international prospective cohort study.

Background

Preoperative SARS-CoV-2 vaccination could support safer elective surgery. Vaccine numbers are limited so this study aimed to inform their prioritization by modelling.

Methods

The primary outcome was the number needed to vaccinate (NNV) to prevent one COVID-19-related death ...
S-EPMC7995808 | biostudies-literature
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