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ProteomicsHeLa Cells Cross-Linked In Vivo versus as a Lysate
HeLa Cells were cross-linked with PIR either in vivo or as a lysate.
ORGANISM(S): Homo sapiens (Human) 
2019-07-12 | PXD013063 | Pride
Pir cross-linker xl-ms 
ProteomicsChemical cross-linking mass spectrometry for systems structural biology in mouse heart tissue.
While modern structural biology technologies have greatly expanded the size and type of protein complexes that can now be studied, the ability to derive large-scale structural information on proteins and complexes as they exist within tissues is practically non-existent. Many protein properties and...
ORGANISM(S): Mus musculus (Mouse) 
2017-11-30 | PXD007673 | Pride
Mass spectrometry Structural biology Mouse Heart Protein-protein interactions Cross-linking 
UnknownSystems structural biology measurements by in vivo cross-linking with mass spectrometry.
Not available
S-EPMC6777709 | biostudies-literature
ProteomicsEffects of a phosphomimetic mutation and nucleotide binding on the interaction of Hsp90a with co-chaperone Aha1 analyzed by chemical cross-linking with mass spectrometry
Complex conformational dynamics are essential for the chaperone function of heat shock protein 90 (Hsp90), including transient, ATP-biased N-domain dimerization establishing ATPase competence. Biochemical data demonstrate that the intrinsic, but weak, ATP hydrolyzing activity of Hsp90 is markedly en...
ORGANISM(S): Homo sapiens (Human) 
2019-06-17 | PXD013476 | Pride
Cross-linking Aha1 Ptm Heat shock Phosphorylation Xl-ms Chaperone Hsp90 
ProteomicsMitochondrial interactome quantitation reveals structural changes in metabolic machinery in failing murine heart
Advancements of cross-linking mass spectrometry (XL-MS) for structural analysis of proteins bridges the gap between purified systems and native tissue environments. Here, we utilize isobaric quantitative protein interaction reporter technology (iqPIR) to further extend XL-MS to the first system-wide...
ORGANISM(S): Mus musculus (Mouse) 
2022-08-02 | PXD027757 | Pride
Quantitative cross-linking  heart failure  cardiac hypertrophy  mitochondria  protein interactions  interactome  mass spectrometry  systems structural biologyquantitative cross-linking  heart failure  cardiac hypertrophy  mitochondria  protein interactions  interactome  mass spectrometry  systems structural biology 
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