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ProteomicsInhibition of histone methyltransferase EZH2 in Schistosoma mansoni by GSK343 decreases the expression of genes implicated in DNA replication and ncRNA metabolism
Schistosomiasis is a chronic and debilitating disease caused by a trematode of the genus Schistosoma. The current strategy for the control of the disease involves treatment with Praziquantel, the only available drug. The development of new drugs is therefore a top priority. Drugs that inhibit histon...
ORGANISM(S): Schistosoma mansoni (Blood fluke) 
2018-11-23 | PXD010342 | Pride
Proteomics Schistosoma mansoni Ezh2 Gsk343 Rna-seq 
TranscriptomicsMycobacteria-Dependent Expression of microRNA-142-3p Reduces WASP Family Proteins and Controls Phagocytosis
Phagocytosis requires the activation of a plethora of mechanisms that include the activation of the actin cytoskeleton guided by the Arp2/3 complex. These are promoted by activators such as the Wiskott Aldrich Syndrome Protein (WASP) family members. In order to further understand the molecular mecha...
ORGANISM(S): Mus musculus 
2013-06-16 | E-GEOD-23429 | biostudies-arrayexpress
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