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ProteomicsProteomic profiling of ubiquitylated proteins in urinary exosomes
Exosomes, derived from multivesicular bodies (MVBs), contain proteins and genetic materials from their cell of origin and are secreted from various cells types, including kidney epithelial cells. In general, it is thought that protein cargo is ubiquitylated, but that ubiquitin is cleaved by specific...
ORGANISM(S): Homo sapiens (Human) 
2016-02-22 | PXD002645 | Pride
Human Ubiquitylated proteins Urine Exosomes 
ProteomicsDeep Characterization of the IFN-I/III-Stimulated Proteome in HBV-Transfected or Native HepG2 Cells
To expand knowledge of the effects of interferon at the proteomic level, we treated HepG2 cells with IFN-alpha and IFN-lambda for 24 hours. HepG2.2.15 cells, a model for HBV infection, were also examined versus controls. MTT assays showed that optimized IFN levels (100 ng/ml) did not induce apoptosi...
ORGANISM(S): Homo sapiens (Human) HBV genotype D 
2020-06-26 | PXD017251 | Pride
Quantitative proteomics Hepatitis b virus Interferon alpha Interferon lambda3 
ProteomicsmTORC2 interactome and localization determine aggressiveness of high-grade glioma cells through association with gelsolin.
The mTOR complex 2 (mTORC2) has been implicated as a key regulator of glioblastoma cell migration. However, the roles of mTORC2 in the migrational control process have not been entirely elucidated. Here we elaborate that mTORC2 is crucial for GBM cell motility. Inhibition of mTORC2 resulted in impai...
ORGANISM(S): Homo sapiens (Human) 
2023-05-10 | PXD035256 | Pride
Glioblastoma Ap-ms Mtorc2 interactome Cell migration Gelsolin 
ProteomicsProteomic profiling of ubiquitylated proteins in urinary exosomes
Exosomes, derived from multivesicular bodies (MVBs), contain proteins and genetic materials from their cell of origin and are secreted from various cells types, including kidney epithelial cells. In general, it is thought that protein cargo is ubiquitylated, but that ubiquitin is cleaved by specific...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-10-21 | MSV000080269 | MassIVE
UnknownThe STING inhibitor (ISD-017) reduces glomerulonephritis in 129.B6.Fcgr2b-deficient mice.
Not available
S-EPMC11094069 | biostudies-literature
UnknownDeubiquitylation of Protein Cargo Is Not an Essential Step in Exosome Formation.
Not available
S-EPMC4858939 | biostudies-literature
ProteomicsMultiple Extracellular Vesicle Types in Peritoneal Dialysis Effluent are Prominent and Contain Known Biomarkers
Proteomics-based analysis of Peritoneal Dialysis Effluent is a relatively new approach to studying the changes associated with PD. Recent studies have shown altered proteomic profiles in various conditions of PD patients, including uremia, diabetes, peritonitis, abnormal peritoneal transport functi...
ORGANISM(S): Homo sapiens (Human) 
2018-08-14 | PXD006371 | Pride
Peritoneal dialysis Extracellular vesicles Proteomics 
ProteomicsComprehensive proteomics identification of IFN-λ3-regulated anti-viral proteins in HBV-transfected cells
Hepatitis B virus (HBV) causes both acute and chronic liver inflammation. Approximately 600,000 CHB patients each year die of HBV-related diseases such as cirrhosis and liver cancer. Therefore, CHB remains a global health concern. Although there have been anti-HBV agents for treating CHB, they have ...
ORGANISM(S): Homo sapiens (Human) 
2018-08-17 | PXD007896 | Pride
Hepatitis b virus Ifn-λ3 Dimethyl labeling Lc-ms/ms 
TranscriptomicsTranscription profiling of rat inner medullary collecting duct
Identification of gene expressed in the enriched inner medullary collecting duct cells in rat. Experiment Overall Design: Rat inner medullary collecting duct (IMCD) cells were isolated from 7 male Sprage-Dawley rats by collagenase and hyaluronidase digestion and follow by low speed centrifugation. T...
ORGANISM(S): Rattus norvegicus 
2008-06-15 | E-GEOD-7891 | biostudies-arrayexpress
UnknownDecreased Protein Kinase C-β Type II Associated with the Prominent Endotoxin Exhaustion in the Macrophage of FcGRIIb-/- Lupus Prone Mice is Revealed by Phosphoproteomic Analysis.
Not available
S-EPMC6472018 | biostudies-literature
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