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ProteomicsForward and reverse degradomics defines the proteolytic landscape of human knee osteoarthritic cartilage and the role of the serine protease HtrA1
Proteolytic destruction of articular cartilage is a major pathogenic mechanism in osteoarthritis (OA), but was not previously investigated on a proteome-wide scale. We sought to define the human knee OA cartilage degradome and the contribution therein of the serine protease HtrA1, using an N-termino...
ORGANISM(S): Homo sapiens (Human) 
2023-11-03 | PXD028320 | Pride
Degradomics Atoms Osteoarthritis N-terminomics Htra1 
ProteomicsProteolytic information flows from human knee osteoarthritic cartilage to synovial fluid and defines the roles of key drug targets -1
Objectives: Proteolytic cartilage loss is a major mechanism of osteoarthritis (OA) pathogenesis but few joint breakdown biomarkers are currently available. We sought to determine the overlap of proteolytic peptides in OA cartilage and synovial fluid on a proteome-wide scale with the goals of increa...
ORGANISM(S): Homo sapiens (Human) 
2025-02-04 | PXD048053 | Pride
Proteolysis Synovial fluid Cartilage Protease Proteomics Osteoarthritis 
ProteomicsForward and reverse degradomics defines the proteolytic landscape of human knee osteoarthritic cartilage and the role of the serine protease HtrA1
Proteolytic destruction of articular cartilage is a major pathogenic mechanism in osteoarthritis (OA), but was not previously investigated on a proteome-wide scale. We sought to define the human knee OA cartilage degradome.
ORGANISM(S): Homo sapiens (Human) 
2023-11-03 | PXD028060 | Pride
Cartilage Serine protease Osteoarthritis Htra1 
UnknownDegradomics defines proteolysis information flow from human knee osteoarthritis cartilage to matched synovial fluid and the contributions of secreted proteases ADAMTS5, MMP13 and CMA1 to articular cartilage breakdown.
Not available
S-EPMC12342059 | biostudies-literature
UnknownHeart failure patients demonstrate excellent 1-year outcomes after total knee arthroplasty despite high healthcare utilization.
Not available
S-EPMC12511152 | biostudies-literature
UnknownTotal hip arthroplasty using a short-stemmed femoral component in the presence of a long dynamic condylar screw osteosynthesis plate.
Not available
S-EPMC4199077 | biostudies-literature
UnknownUnderstanding the 30-day mortality burden after revision total knee arthroplasty.
Not available
S-EPMC8502837 | biostudies-literature
UnknownStandardized quantification of biofilm in a novel rabbit model of periprosthetic joint infection.
Not available
S-EPMC9051660 | biostudies-literature
UnknownTotal Hip Arthroplasty for Developmental Dysplasia of Hip vs Osteoarthritis: A Propensity Matched Pair Analysis.
Not available
S-EPMC7502580 | biostudies-literature
UnknownA comprehensive dataset of histopathology images, grades and patient demographics for human Osteoarthritis Cartilage.
Not available
S-EPMC8170068 | biostudies-literature
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