Sort   by:  
 Page size 
ProteomicsRecombinant TSP1 cleaved by HTRA1 (LCMS)
HTRA1 proteolysis of TSP1 inhibits immune suppression in age-related macular degeneration. A minor haplotype of the 10q26 locus conveys the strongest genetic risk for age related macular degeneration (AMD), a major cause of blindness affecting millions of individuals worldwide. Here we show that mo...
ORGANISM(S): Homo sapiens (Human) 
2020-07-25 | PXD020546 | Pride
Tsp1 Htra1 
TranscriptomicsHtrA1-dependent proteolysis of TGF-M-NM-2 controls both neuronal maturation and developmental survival
Transforming growth factor-M-NM-2 (TGF-M-NM-2) signalling controls a number of cerebral functions and dysfunctions including synaptogenesis, amyloid-M-NM-2 accumulation, apoptosis and excitotoxicity. Using cultured cortical neurons prepared from either wild type or transgenic mice over-expressing a ...
ORGANISM(S): Homo sapiens 
2008-04-15 | E-GEOD-11162 | biostudies-arrayexpress
ProteomicsHTRA1 dependent cell cycle proteomics
The HTRA1 gene encoding an evolutionary conserved protein quality control factor can be epigenetically silenced or inactivated by mutation under pathologic conditions such as cancer. Recent evidence suggests that loss of HTRA1 function causes multiple phenotypes including acceleration of cell growth...
ORGANISM(S): Homo sapiens (Human) 
2019-02-15 | PXD007079 | Pride
Label-free quantification Htra1 Cell cycle 
ProteomicsForward and reverse degradomics defines the proteolytic landscape of human knee osteoarthritic cartilage and the role of the serine protease HtrA1
Proteolytic destruction of articular cartilage is a major pathogenic mechanism in osteoarthritis (OA), but was not previously investigated on a proteome-wide scale. We sought to define the human knee OA cartilage degradome and the contribution therein of the serine protease HtrA1, using an N-termino...
ORGANISM(S): Homo sapiens (Human) 
2023-11-03 | PXD028320 | Pride
Degradomics Atoms Osteoarthritis N-terminomics Htra1 
ProteomicsRational correction of pathogenic conformational defects in HTRA1
Loss-of-function mutations in the homotrimeric serine protease HTRA1 cause cerebral vasculopathy. Here, we show that disease-causing mutations targeting the protomer-protomer interface impair trimerization. Focusing on a prototypical interface mutation (R274Q), we designed an HTRA1 variant that comp...
ORGANISM(S): Mus musculus (Mouse) 
2023-11-24 | PXD024683 | Pride
Mouse Kidney Podocytes 
ProteomicsN-terminomic analysis of RPE secretome
Identification of HtrA1 substrate in the context of RPE secretome
ORGANISM(S): Homo sapiens (Human) 
2018-04-09 | PXD007139 | Pride
Human rpe Htra1 
GenomicsHTRA1 Mutation and Expression Regulation in Cerebral Small Vessel Disease
HTRA1 Mutation and Expression Regulation in Cerebral Small Vessel Disease
PRJNA1433271 | ENA
GenomicsComparative transcriptome data of ARPE-19 cells with and without HTRA1 overexpression
Comparative transcriptome data of ARPE-19 cells with and without HTRA1 overexpression
PRJNA776175 | ENA
TranscriptomicsHTRA1 Mutation and Expression Regulation in Cerebral Small Vessel Disease
Cerebral small vessel disease (CSVD) refers to a series of clinical, radiological, and pathological syndromes caused by various etiologies affecting small arteries, arterioles, venules, capillaries, and small veins in the brain. It can lead to cognitive impairment, stroke, gait abnormalities, and ot...
ORGANISM(S): Homo sapiens 
2026-03-11 | GSE324041 | GEO
ProteomicsAlpha-1-Antitrypsin: A Novel Human High Temperature Requirement Protease A1 (HTRA1) Substrate in Human Placental Tissue
Substrate screening of the human protease HTRA1 in a placenta protein extract. The human serine protease high temperature requirement A1 (HTRA1) is highly expressed in the placental tissue, especially in the last trimester of gestation. This suggests that HTRA1 is involved in placental formation and...
ORGANISM(S): Homo sapiens (Human) 
2014-10-24 | PXD000473 | Pride
A1at Htra1 Substrates screening Placenta 2de-gel electrophoresis 
Sort   by:  
 Page size