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MetabolomicsPKA regulates stress granule maturation to allow timely recovery after prolonged starvation
Cells have evolved multiple strategies to survive environmental stress conditions. This includes the formation of membrane-less cytoplasmic ribonucleoprotein structures called stress granules that sequester and protect mRNAs encoding many housekeeping genes. Stress granules are not static biomolecul...
2026-06-16 | MTBLS13923 | MetaboLights
MetabolomicsF1Fo-ATP synthase subunit determines lethal pathogenic fungi infection
Fungal infections, especially candidiasis and aspergillosis, claim an unacceptably high fatality rate. The energy ATP that is necessary for fungal cell growth and function is synthesized mainly through oxidative phosphorylation, with the key enzyme being F1Fo-ATP synthase. But it remains unknown how...
2021-10-08 | MTBLS3332 | MetaboLights
MetabolomicsSemen Cuscutae flavonoids activated the cAMP-PKA-CREB-BDNF pathway and exerted an antidepressant effect in mice

Background: Semen Cuscutae flavonoids (SCFs) constitute a class of metabolites of Semen Cuscutae, a botanical drug that was recently found to have an anti-depression effect. This study aimed to evaluate the anti-depression effects of SCFs in chronic unpredi...

2025-05-12 | MTBLS11688 | MetaboLights
ProteomicsSmoothened Transduces Hedgehog Signals via Activity-Dependent Sequestration of PKA Catalytic Subunits
The Hedgehog (Hh) pathway is essential for organ development, homeostasis, and regeneration. Dysfunction of this cascade drives several cancers. To control expression of pathway target genes, the G protein-coupled receptor (GPCR) Smoothened (SMO) activates glioma-associated (GLI) transcription facto...
ORGANISM(S): Homo Sapiens 
2021-04-25 | PXD023893 | panorama
ProteomicsProteomic and phosphoproteomic analyses of protein PKA catalytic-alpha-null mpkCCD cells and PKA catalytic-beta-null mpkCCD cells.
Protein Kinase A (PKA) is a widely studied protein that has been viewed by most investigators as a single entity, although its catalytic subunits are coded in the genome by two separate genes, PKA catalytic alpha (Gene symbol: Prkaca) and PKA catalytic beta Gene symbol: Prkacb). At an amino-acid le...
ORGANISM(S): Mus musculus (Mouse) 
2020-06-01 | PXD015050 | Pride
Phosphoproteomics Pka catalytic subunit Kidney Pka Mouse Proteomics Kinase Mpkccd 
ProteomicsIdentification and phosphorylation site mapping of a sperm specific PKA C subunit isoform from Mytilus galloprovincialis
This project investigates a sperm-specific isoform of the catalytic (C) subunit of cAMP-dependent protein kinase (PKA) in the marine mussel Mytilus galloprovincialis, an externally fertilizing invertebrate widely used as a model for gamete activation studies. A C-subunit isoform purified from male g...
ORGANISM(S): Crenomytilus 
2026-09-07 | PXD076788 | Pride
Camp-dependent protein kinase  pka  catalytic subunit  lc–ms/ms  phosphoproteomics  phosphorylation sites  tio₂ enrichment  mytilus galloprovincialis  sperm 
ProteomicsYeast PKA holoenzyme and condensate targeted and label-free proteomics
Protein kinase A (PKA) is a conserved kinase essential for many biological processes linked to growth, development and metabolism. The PKA catalytic subunit is expressed as multiple isoforms in diverse eukaryotes; however, their contribution to ensuring specificity in response to environmental cues ...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2025-09-19 | PXD045310 | Pride
Holoenzyme Yeast Condensates Heat stress Pka isoforms 
TranscriptomicsGlobal regulatory roles of the cAMP/PKA pathway revealed by phenotypic, transcriptomic, and phosphoproteomic analyses in a null mutant of PKA catalytic subunit in Candida albicans
The conserved cAMP-dependent protein kinase (PKA) holoenzyme is composed of two catalytic and two regulatory subunits. It plays critical roles in the regulation of many biological processes in eukaryotic organisms. In the human fungal pathogen Candida albicans, the PKA kinase has been extensively in...
ORGANISM(S): Candida albicans 
2017-08-18 | GSE92621 | GEO
UnknownConstitutive activation of PKA catalytic subunit in adrenal Cushing's syndrome.
Not available
S-EPMC4727447 | biostudies-literature
UnknownPKA catalytic subunit compartmentation regulates contractile and hypertrophic responses to β-adrenergic signaling.
Not available
S-EPMC3927644 | biostudies-literature
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